- Poster presentation
- Open Access
Dependence of detectability of microcalcification clusters on quality of mammography images
Breast Cancer Research volume 13, Article number: P23 (2011)
This work compares the detection of microcalcification clusters (MC) in digital mammography images with different image quality levels.
A total of 162 normal breast images were acquired on an a-Se DR system. MC clusters extracted from magnified images of sliced mastectomies were electronically inserted into half of the images. The majority of clusters used were subtle. All images were adjusted mathematically using a validated method to simulate the appearance of images from a CR imaging system at the same dose and on both systems at half this dose. Seven experienced observers marked the location of suspicious regions, assigning a five-point score for confidence that the suspicious region was a cluster. The data were analysed using the area under the alternative free-response receiver operating characteristic (AFROC) and the area under the receiver operating characteristic (ROC) as figures of merit.
There was a significant reduction in detection using CR compared with DR; the AFROC area decreased from 0.83 to 0.63 and the ROC area decreased from 0.91 to 0.79 (P < 0.0001). A significant reduction in detection was also evident at half the original dose for both DR and CR.
The detection of subtle clusters was reduced significantly with CR compared with DR and it is possible that CR will miss cancers manifesting as microcalcification that would be found by DR. Calcification detection was sensitive to the dose used, which should be reflected in image quality standards to ensure adequate image quality is achieved even at the cost of a higher dose.
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Warren, L., Mackenzie, A., Cooke, J. et al. Dependence of detectability of microcalcification clusters on quality of mammography images. Breast Cancer Res 13 (Suppl 1), P23 (2011). https://doi.org/10.1186/bcr2975
- Image Quality
- Receiver Operating Characteristic
- Digital Mammography
- Mammography Image
- Adequate Image