Table 8 MAP-tau expression levels and response to docetaxel in TAX 307S
TAX 307S Patient groups | N | Objective response4 (CR + PR) (%) | Stable disease5 (SD) (%) | Progressive disease (PD) (%) | Total | Missing | P* |
|---|---|---|---|---|---|---|---|
ER positive | Â | Â | Â | Â | Â | Â | 0.174 |
High MAP-tau | Â | 15 (33.3) | 5 (11.1) | 1 (2.2) | 21 (46.7) | Â | Â |
Low MAP-tau | Â | 10 (22.2) | 10 (22.2) | 4 (8.9) | 24 (53.3) | Â | Â |
Total | 50 | 25 (55.8) | 15 (33.3) | 5 (11.1) | 45 (100.0) | 5 | Â |
ER negative | Â | Â | Â | Â | Â | Â | 0.721 |
High MAP-tau | Â | 4 (10.5) | 4 (10.5) | 0 (0.0) | 8 (21.0) | Â | Â |
Low MAP-tau | Â | 15 (39.5) | 13 (34.2) | 2 (5.3) | 30 (78.9 | Â | Â |
Total | 40 | 19 (49.9) | 17 (44.8) | 2 (5.3) | 38 (100.0) | 2 | Â |
FAC 1 and TAC 2 | Â | Â | Â | Â | Â | Â | 0.518 |
High MAP-tau | Â | 20 (19.7) | 9 (8.9) | 3 (2.9) | 32 (31.7) | Â | Â |
Low MAP-tau | Â | 36 (35.6 | 20 (19.8) | 13 (12.9) | 69 (68.3) | Â | Â |
Total | 108 | 56 (55.4) | 29 (28.7) | 16 (15.8) | 101 (100.0) | 7 | Â |
TAC 2 only | Â | Â | Â | Â | Â | Â | 0.250 |
High MAP-tau | Â | 11 (22.4) | 7 (14.3) | 1 (2.0) | 19 (38.8) | Â | Â |
Low MAP-tau | Â | 17 (34.7) | 7 (14.3) | 6 (12.2) | 30 (61.2) | Â | Â |
Total | 54 | 28 (57.1) | 14 (28.6) | 7 (14.3) | 49 (100.0) | 5 | Â |
TAC 2 and ER positive | Â | Â | Â | Â | Â | Â | 0.520 |
High MAP-tau | Â | 9 (45.0) | 4 (20.0) | 1 (5.0) | 14 (70.0) | Â | Â |
Low MAP-tau | Â | 2 (10.0) | 3 (15.0) | 1 (5.0) | 6 (30.0) | Â | Â |
Total | 20 | 11 (55.0) | 7 (35.0) | 2 (10.0) | 20 (100.0) | 0 | Â |
TAC 2 /ER negative/Adj Hormonal -negative 3 | Â | Â | Â | Â | Â | Â | 0.222 |
High MAP-tau | Â | 2 (10.0) | 2 (10.0) | 0 (0.0) | 4 (20.0) | Â | Â |
Low MAP-tau | Â | 8 (40.0) | 3 (15.0) | 5 (25.0) | 16 (80.0) | Â | Â |
Total | 20 | 10 (50.0) | 5 (25.0) | 5 (25.0) | 20 (100.0) | 0 | Â |
FAC 1 only | Â | Â | Â | Â | Â | Â | 0.514 |
High MAP-tau | Â | 9 (17.3) | 2 (3.9) | 2 (3.9) | 13 (25.0) | Â | Â |
Low MAP-tau | Â | 19 (36.6) | 13 (25.0) | 7 (13.5) | 39 (75.0) | Â | Â |
Total | 54 | 28 (53.9) | 15 (28.9) | 9 (17.3) | 52 (100.0) | 2 | Â |
FAC 1 and ER positive | Â | Â | Â | Â | Â | Â | 0.105 |
High MAP-tau | Â | 6 (24.0) | 1 (4.0) | 0 (0.0) | 7 (28.0) | Â | Â |
Low MAP-tau | Â | 8 (32.0) | 7 (28.0) | 3 (12.0) | 18 (72.0) | Â | Â |
Total | 28 | 14 (56.0) | 8 (32.0) | 3 (12.0) | 25 (100.0) | 3 | Â |
FAC 1 and ER negative | Â | Â | Â | Â | Â | Â | 0.919 |
High MAP-tau | Â | 2 (11.1) | 1 (5.6) | 1 (5.6) | 4 (22.2) | Â | Â |
Low MAP-tau | Â | 7 (38.9) | 5 (27.8) | 2 (11.1) | 14 (77.8) | Â | Â |
Total | 18 | 9 (50.0) | 6 (33.3) | 3 (16.7) | 18 (100.0) | 0 | Â |