Figure 1
From: β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib
Phosphorylated levels of β1 downstream kinases are increased upon acquisition of resistance to lapatinib (L). (A) Parental (P) BT474 and (B) HCC1954 cells resistant to lapatinib (LRes), trastuzumab (TRes), and combination (LTRes) treatment strategies were developed by long-term exposure in 2D. Protein extracts were probed for β1, pHER2, pFAK, and pSrc, as well as totals.