The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions

Table 1 Mammary gland transplantation data and logistic regression analysis

MG transplantation data^a						Logistic regression analysis^b
	S:S	S:R	R:S	R:R	Total		Independent	Coefficient	Pvalue
Transplant MG present	31	72	22	88	213	MG transplantation efficiency	Donor effect	-0.3502	0.6449
Transplant MG absent	6	11	3	11	31		Recipient effect	-0.4372	0.4423
Percentage of MG present	84%	87%	88%	89%	87%		Donor × recipient	0.3389	0.7056
0 carcinomas	15	50	12	66	143
1 carcinoma	13	17	10	19	59	MG transplant carcinoma susceptibility	Donor effect	-0.2468	0.6588
2 carcinomas	3	4	0	3	10		Recipient effect	-0.8855	0.0447^c
3 carcinomas	0	1	0	0	1		Donor × recipient	0.0307	0.9629
Percentage of MGs with 1 carcinoma	52%	31%	45%	25%	33%

^aTransplant groups (donor/recipient): S:S, susceptible/susceptible; S:R, susceptible/resistant; R:S, resistant/susceptible; R:R, resistant/resistant. ^bLogistic regression was used to estimate the effect of donor and recipient and the interaction between donor and recipient for the dependent variables mammary gland (MG) transplantation efficiency (outcome = histologically determined presence or absence of MG development at transplant site) and MG transplant carcinoma susceptibility (outcome = tumor presence or absence at transplant site) in susceptible congenic control and Mcs5a-resistant congenic reciprocal (donor, recipient) transplant groups. ^cStatistically significant.

ISSN: 1465-542X