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Table 1 Sequential treatment using different classes of aromatase inhibitors

From: Understanding the mechanisms of aromatase inhibitor resistance

Initial treatment Second treatment n Objective
response (%)
Clinical
benefit (%)
Time to progression
(months)
Reference
Anastrozole or letrozole Exemestane 23 8.7 43.5 5.1 [37]
Exemestane Anastrozole or letrozole 18 22.2 55.6 9.3 [37]
Anastrozole Exemestane 12    4.4 [73]
Exemestane Anastrozole 11    1.9 [73]
Anastrozole Exemestane 50 8.0 44.0 5.0 [74]
Anastrozole or letrozole Exemestane 114 5.0 46.0 4.5 [75]
Anastrozole or letrozole Exemestane 31 19.4 54.8 3.2 [76]
Anastrozole or letrozole Exemestane 30 0.0 46.6 4.0 [77]
Anastrozole or letrozole Exemestane 60 20.0 38.3 3.2 [78]
Anastrozole or letrozole Exemestane 105 4.8 20 3.2 [36]