Table 1 Sequential treatment using different classes of aromatase inhibitors
From: Understanding the mechanisms of aromatase inhibitor resistance
Initial treatment | Second treatment | n | Objective response (%) | Clinical benefit (%) | Time to progression (months) | Reference |
|---|---|---|---|---|---|---|
Anastrozole or letrozole | Exemestane | 23 | 8.7 | 43.5 | 5.1 | [37] |
Exemestane | Anastrozole or letrozole | 18 | 22.2 | 55.6 | 9.3 | [37] |
Anastrozole | Exemestane | 12 | 4.4 | [73] | ||
Exemestane | Anastrozole | 11 | 1.9 | [73] | ||
Anastrozole | Exemestane | 50 | 8.0 | 44.0 | 5.0 | [74] |
Anastrozole or letrozole | Exemestane | 114 | 5.0 | 46.0 | 4.5 | [75] |
Anastrozole or letrozole | Exemestane | 31 | 19.4 | 54.8 | 3.2 | [76] |
Anastrozole or letrozole | Exemestane | 30 | 0.0 | 46.6 | 4.0 | [77] |
Anastrozole or letrozole | Exemestane | 60 | 20.0 | 38.3 | 3.2 | [78] |
Anastrozole or letrozole | Exemestane | 105 | 4.8 | 20 | 3.2 | [36] |