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Table 1 Characteristics of some histone methyltransferase and demethylase inhibitors

From: Epigenetics in breast cancer: what's new?

Inhibitor

Major targeted enzymes

Changed histone marks

Citation

Chaetocin1

Suv39h1, G9a

H3K9

[48]

DZNep

EZh2

H3K27

[49]

Novobiocin

SMYD3

H3K4

[51]

Trancylpromine, clorgyline, pargyline

LSD1, LSD2

H3K4, H3K9

[35, 52, 53]

Polyamine analogs

LSD1

H3K4

[54, 55]

N-oxalylglycine

JMJD2A, JMJD2C

H3K9, H3K36

[57]