Skip to main content
Figure 6 | Breast Cancer Research

Figure 6

From: Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer

Figure 6

Increased STAT5 initiates cancer and decreased STAT5 diminishes cancer promotion in genetically engineered mouse models. Increased levels of STAT5 expression and/or activation either directly by transgene-mediated STAT5 overexpression or indirectly through genetically engineered loss of caveolin-1 leads to initiation, promotion, and progression to mammary cancer. Decreased levels of STAT5 expression reduce cancer promotion initiated by transgene-mediated overexpression of prolactin, transforming growth factor-alpha (TGF-α), and estrogen receptor-alpha (ERα) as well as mammary-targeted simian virus 40 T antigen. STAT5, signal transducer and activator of transcription 5.

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us