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Figure 2 | Breast Cancer Research

Figure 2

From: Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10

Figure 2

FGFR2 mRNA expression levels in fibroblasts cultured from different locations. (A) We found a significant correlation between FGFR2 mRNA expression in skin fibroblasts and normal breast fibroblasts from the same patient (n = 22). The FGFR2 expression levels were log2-transformed and normalized to HNRPM and TBP expression. (B) FGFR2 mRNA expression in tumor-derived fibroblasts is significantly higher than in fibroblasts cultured from normal breast tissue. The FGFR2 expression levels were log2-transformed and normalized to HNRPM and TBP expression. Each dot represents FGFR2 expression in one patient. The lines connect the fibroblast cultures from one patient. The horizontal bars shows the mean expression for all fibroblast cultures from that origin (skin -3.8 (±1.9 SD), normal breast -2.9 (±1.4 SD), tumor tissue 0.2 (±1.5 SD)). *P < 0.001.

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