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Figure 6 | Breast Cancer Research

Figure 6

From: Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes

Figure 6

Breast tumors with basal-like gene expression and basal epithelial cells differentially express hypoxia-related genes. A significant positive correlation between basal-like and hypoxia-related gene expression was observed in breast tumors in the (A) primary (n = 1,143, P <0.0001) and (D) validation (n = 547, P <0.0001) datasets. A significant positive relationship was observed between HIF-1α gene expression and hypoxia-related gene expression in the (B) primary (n = 1,143, P <0.0001) and (E) validation (n = 547, P <0.0001) datasets. A significant positive relationship was observed between HIF-1α gene expression and basal-like gene expression in the (C) primary (n = 1,143, P <0.0001) and (F) validation (n = 547, P <0.0001) datasets. (G) Normal basal epithelial cells express higher mRNA levels of HIF-1α (P <0.0001) and EPAS1 (HIF-2α) (P <0.0001) as compared to normal breast luminal cells. (H) Normal basal epithelial cells demonstrate higher mRNA levels of three hypoxia-induced genes (CA9, Glut1, and VEGFA) under normal and hypoxic conditions as compared to normal luminal epithelia.

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Breast Cancer Research

ISSN: 1465-542X

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