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Table 5 Prognostic factors by multivariate analysis for disease-free and overall survival

From: Cytokeratin-19 mRNA-positive circulating tumor cells during follow-up of patients with operable breast cancer: prognostic relevance for late relapse

  DFS Overall survival
  HR 95% CI P-value HR 95% CI P-value
Menopausal status
Post vs Pre
1.462 0.858 to 2.492 0.163 1.365 0.794 to 2.347 0.260
Tumor status
T2/T3 vs T1
2.187 1.167 to 4.098 0.015 2.135 1.141 to 3.994 0.018
Nodes
N> 3 vs N0-3
1.801 1.080 to 3.003 0.024 2.150 1.109 to 4.168 0.023
CK-19 at five years FU
Persistently negative
Turn to negative
Turn to positive
Persistently positive (ref)
0.328
0.206
0.622
0.157 to 0.683
0.081 to 0.526
0.327 to 1.186
0.003
0.001
0.149
0.001
0.330
0.201
0.587
0.159 to 0.688
0.079 to 0.514
0.309 to 1.115
0.003
0.001
0.104
0.001
  1. CK-19, cytokeratine-19; CMF, cyclophosphamide-methotraxate-fluorouracil; DFS, disease-free survival; ER, estrogen receptor; FEC, fluorouracil-epirubicin-cyclophosphamide; PR, progesteron receptor; T/EC, taxane/epirubicin-cyclophosphamide.