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Figure 4 | Breast Cancer Research

Figure 4

From: Estrogen receptor β represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity

Figure 4

Effect of ERβ on heregulin-β1-activated HER2, HER3 and Akt. (A) T47-DERβ cells were treated for 4 days with 10 ng/mL (-ERβ) or 0.01 ng/mL (+ERβ) doxycycline in the presence or absence of 10 nM DPN with or without 100 nM ICI or 100 nM 4-OH-T and stimulated with heregulin-β1 (HRG-β1) for 30 minutes. (B) T47-DERβ cells were treated as described above and stimulated with HRG-β1 for 30 minutes up to 24 hours. Lysates were analyzed by immunoblotting.

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Breast Cancer Research

ISSN: 1465-542X

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