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Table 2 Selected ontologies of commonly downregulated genes

From: The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines

Term Genesa Gene set on the array Z-score
Biological process    
   Cell cycle 20 957 4.42
   Spindle organizationb 4 54 5.31
   DNA metabolic process 18 559 6.32
   DNA replicationb 13 228 8.13
   DNA-dependent DNA replicationb 5 71 5.75
   DNA-dependent DNA replication initiationb 3 25 6.13
Cellular component    
   Chromosomal part 13 381 5.57
   Condensed chromosome kinetochoreb 4 69 4.52
   Replication forkb 3 33 5.2
Molecular function    
   Transmembrane receptor protein tyrosine kinase activity 4 64 4.81
   DNA helicase activity 3 41 4.6
   Insulin-like growth factor binding 3 24 6.32
  1. aNumber of genes differentially expressed within the assigned ontology. bSubcategory within a given ontology.