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Table 2 Selected ontologies of commonly downregulated genes

From: The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines

Term

Genesa

Gene set on the array

Z-score

Biological process

   

   Cell cycle

20

957

4.42

   Spindle organizationb

4

54

5.31

   DNA metabolic process

18

559

6.32

   DNA replicationb

13

228

8.13

   DNA-dependent DNA replicationb

5

71

5.75

   DNA-dependent DNA replication initiationb

3

25

6.13

Cellular component

   

   Chromosomal part

13

381

5.57

   Condensed chromosome kinetochoreb

4

69

4.52

   Replication forkb

3

33

5.2

Molecular function

   

   Transmembrane receptor protein tyrosine kinase activity

4

64

4.81

   DNA helicase activity

3

41

4.6

   Insulin-like growth factor binding

3

24

6.32

  1. aNumber of genes differentially expressed within the assigned ontology. bSubcategory within a given ontology.
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Breast Cancer Research

ISSN: 1465-542X

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