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Table 2 Differentially expressed microRNA among pooled reduction mammoplasty, histologically normal and ductal carcinoma in situa

From: Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer

  HN versus PRM DCIS versus PRM DCIS versus HN
microRNA Fold change Pvalueb Fold change Pvalueb Fold change Pvalueb
let-7c [62] 15.23 3.46E-03c 0.31 1.25E-01 0.03 1.19E-03c
miR-7 [38] 3.12 1.35E-01 22.35 1.53E-03c 5.19 4.92E-02
miR-10b [13, 39] 2.90 1.59E-01 0.82 7.82E-01 0.04 2.58E-03c
miR-17-3p [32, 40] 19.04 2.14E-03c 2.20 2.85E-01 0.12 1.73E-02
miR-18a [34] 1.91 3.76E-01 20.88 1.76E-03c 3.53 1.12E-01
miR-21 [13, 31, 36, 40, 41] 6.74 2.23E-02 55.20 2.64E-04c 20.92 3.21E-03c
miR-93[34] 7.53 1.72E-02 193.86 3.33E-05d 160.47 1.59E-04d
miR-99a 1.90 3.79E-01 0.53 3.79E-01 0.02 9.19E-04c
miR-99b 3.08 1.39E-01 14.84 3.66E-03c 6.24 3.33E-02
miR-125b [13, 29] 0.93 9.24E-01 0.08 5.39E-03c 0.05 4.03E-03c
miR-127 [30, 31] 1.77 4.30E-01 0.25 7.81E-02 0.02 5.30E-04c
miR-130a 0.29 1.06E-01 0.01 1.38E-04d 0.09 1.01E-02
miR-145 [13, 14] 3.00 1.47E-01 0.80 7.52E-01 0.03 1.20E-03c
miR-181b [31, 40] 3.40 1.11E-01 14.90 3.64E-03c 5.46 4.42E-02
miR-182 [33] 2.00 3.45E-01 106.24 8.54E-05d 72.35 4.55E-04c
miR-183 2.52 2.15E-01 19.06 2.14E-03c 51.88 7.38E-04c
miR-191 [13] 6.75 2.23E-02 78.21 1.43E-04d 31.59 1.60E-03c
miR-193b [18] 2.20 2.84E-01 15.67 3.25E-03c 6.87 2.73E-02
miR-195 [35] 1.37 6.57E-01 0.06 2.78E-03c 0.13 2.15E-02
miR-200b [37] 1.70 4.63E-01 6.07 2.86E-02 51.31 7.50E-04c
miR-200c [37] 1.90 3.80E-01 26.41 1.08E-03c 19.98 3.48E-03c
miR-204 [13] 0.77 7.12E-01 0.04 1.32E-03c 0.08 8.12E-03c
miR-324-5p 2.86 1.64E-01 24.38 1.28E-03c 92.53 3.24E-04c
miR-365 [31] 4.05 7.45E-02 17.65 2.51E-03c 25.05 2.35E-03c
miR-376a 0.45 2.73E-01 0.06 3.14E-03c 0.24 7.91E-02c
miR-382 2.03 3.32E-01 0.11 1.20E-02c 0.06 4.71E-03c
miR-383 [34] 0.05 2.15E-03c 0.01 1.58E-04d 0.62 5.18E-01
miR-410 0.96 9.56E-01 0.15 2.33E-02c 0.00 1.11E-04d
miR-425-5p 1.38 6.57E-01 9.47 1.01E-02c 74.46 4.37E-04c
miR-449a 10.65 7.71E-03c 15.12 3.52E-03c 2.53 2.23E-01
miR-449b 0.79 7.37E-01 11.57 6.39E-03c 21.20 3.13E-03c
miR-486 0.02 2.06E-04d 0.01 9.73E-05d 0.34 1.65E-01
miR-489 0.06 2.73E-03c 0.10 8.61E-03c 0.25 8.62E-02
miR-511 0.40 2.20E-01 0.07 3.72E-03c 0.18 4.11E-02
miR-517c 0.07 3.48E-03c 0.01 1.29E-04d 0.36 1.82E-01
  1. aRM, reduction mammoplasty; PRM, pooled reduction mammoplasty; HN, histologically normal; DCIS, ductal carcinoma in situ; microRNA in boldface type have previously been implicated in invasive breast cancer; bP value determined by Student's t-test; cP < 1.7E-02 implies significance with a false-discovery rate of 0.05; dP < 2.5E-04 implies significance after the Bonferroni correction; fold change in expression between comparisons was considered significant if P < 5E-02.