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Table 2 Univariate and multivariate Cox regression analysis of factors associated with relapse-free survival in triple negative breast cancer

From: Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis

  Univariate Multivariate
Variables HR 95% CI P-value HR 95% CI P-value
Age       
   <35 years 1    -   
   ≥35 years 0.77 0.33 to 1.76 0.529    
Performance status       
   ECOG0 1    -   
   ECOG1 1.41 0.54 to 3.70 0.483    
   ECOG2 4.29 0.83 to 22.17 0.082    
Initial clinical stage       
   IIA, IIB 1    1   
   IIIA 9.75 1.30 to 73.30 0.027 7.51 0.98 to 57.83 0.053
   IIIB 9.59 1.18 to 77.94 0.034 7.72 0.92 to 64.93 0.060
   IIIC 18.59 2.37 to 146.04 0.005 14.75 1.74 to 125.11 0.014
Pathologic N stage       
   pN0 1    1   
   pN1 3.79 1.47 to 9.77 0.006 5.87 2.08 to 16.59 0.001
   pN2 4.14 1.33 to 12.88 0.014 4.95 1.45 to 16.91 0.011
   pN3 6.51 2.09 to 20.26 0.001 7.54 2.14 to 26.56 0.002
bcl-2       
   Negative 1    -   
   Positive 0.87 0.43 to 1.76 0.691    
p53       
   Negative 1    -   
   Positive 1.05 0.52 to 2.16 0.885    
Histologic grade       
   II 1    1   
   III 3.37 1.03 to 11.06 0.045 2.04 0.57 to 7.37 0.275
Ki-67       
   Low Ki-67 1    1   
   High Ki-67 4.64 1.41 to 15.22 0.011 7.82 2.18 to 28.13 0.002
   Continuous a 1.02 1.01 to 1.03 0.003 -   
  1. Abbreviations: CI, confidence interval; HR, hazard ratio.
  2. a Entered as continuous variable.