Table 1 Distribution of immunoscoring for hypoxia pathway factors and cut-off values used in semiquantitative analyses

Hypoxia-inducible factor-1α

   0

33 (19.3%)

   1

100 (58.5%)

   2

38 (22.2%)

   Missing

16

Vascular endothelial growth factor

   0

32 (20.0%)

   1

39 (24.4%)

   2

37 (23.1%)

   4

52 (32.5%)

   Missing

27

Carbonic anhydrase IX

   0

125 (75.3%)

   1

20 (12.1%)

   ≥2

21 (12.6%)

   Missing

21

Prolyl hydroxylase 1

   0

129 (73.3%)

   1

43 (24.4%)

   2

3 (1.7%)

   3

1 (0.6%)

   Missing

11

Prolyl hydroxylase 2

   0

78 (47.8%)

   1

51 (31.3%)

   2

30 (18.4%)

   3

4 (2.4%)

   Missing

24

Prolyl hydroxylase 3

   0

108 (61.0%)

   1

53 (29.9%)

   2

15 (8.5%)

   3

1 (0.6%)

   Missing

10