Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers

Lamy, Pierre-Jean; Fina, Frédéric; Bascoul-Mollevi, Caroline; Laberenne, Anne-Claire; Martin, Pierre-Marie; Ouafik, L'Houcine; Jacot, William

doi:10.1186/bcr2824

Table 3 Gene amplification quantification relative to the SSTR2 reference gene^a

From: Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers

Gene	Number of patients (%) (n= 86)	Median (range)
MED1
Deletion	3 (3.5%)	0.5 (0.5 to 0.5)
Normal	27 (31.4%)	0.9 (0.6 to 1.9)
Amplification	56 (65.1%)	4.6 (2 to 27.8)
Total	86 (100.0%)	2.6 (0.5 to 27.8)
STARD3
Deletion	0	-
Normal	6 (7.0%)	1.5 (0.7 to 1.9)
Amplification	80 (93.0%)	6.4 (2.0 to 74.9)
Total	86 (100.0%)	5.9 (0.7 to 74.9)
HER2
Amplification	86 (100.0%)	6.4 (2 to 32)
GRB7
Deletion	0	-
Normal	2 (2.3%)	1.1 (0.6 to 1.7)
Amplification	84 (97.7%)	6.8 (2.3 to 36.5)
Total	86 (100.0%)	6.6 (0.6 to 36.5)
THRA
Deletion	1 (1.2%)	0.5
Normal	38 (44.2%)	1.1 (0.6 to 1.9)
Amplification	47 (54.7%)	4.4 (2.0 to 11.7)
Total	86 (100.0%)	2.2 (0.5 to 11.7)
RARA
Deletion	3 (3.5%)	0.5 (0.4 to 0.5)
Normal	60 (69.8%)	1.0 (0.6 to 1.9)
Amplification	23 (26.7%)	3.4 (2.0 to 11.1)
Total	86 (100.0%)	1.1 (0.4 to 11.1)
TOP2A
Deletion	4 (4.7%)	0.5 (0.5 to 0.5)
Normal	59 (68.6%)	1.0 (0.6 to 1.8)
Amplification	23 (26.7%)	3.2 (2 to 7)
Total	86 (100.0%)	1.1 (0.5 to 7)
IGFBP4
Deletion	5 (5.8%)	0.5 (0.5 to 0.5)
Normal	63 (73.3%)	1.0 (0.6 to 1.9)
Amplification	18 (20.9%)	3.1 (2 to 8)
Total	86 (100.0%)	1.1 (0.5 to 8)
CCR7
Deletion	3 (3.5%)	0.4 (0.4 to 0.5)
Normal	65 (75.6%)	0.9 (0.6 to 1.8)
Amplification	18 (20.9%)	3.3 (2 to 14.9)
Total	86 (100.0%)	1.0 (0.4 to 14.9)
KRT20
Deletion	2 (2.3%)	0.5 (0.5 to 0.5)
Normal	72 (83.7%)	1.1 (0.6 to 1.8)
Amplification	12 (14.0%)	3.1 (2.3 to 11.6)
Total	86 (100.0%)	1.1 (0.5 to 11.6)
KRT19
Deletion	5 (5.8%)	0.5 (0.5 to 0.5)
Normal	71 (82.6%)	1.0 (0.6 to 1.8)
Amplification	10 (11.6%)	3.0 (2 to 6.4)
Total	86 (100.0%)	1.0 (0.5 to 6.4)
GAS
Deletion	2 (2.3%)	0.5 (0.4 to 0.5)
Normal	78 (90.7%)	1.0 (0.6 to 1.7)
Amplification	6 (7.0%)	2.8 (2 to 14.4)
Total	86 (100.0%)	1.0 (0.4 to 14.4)

^aAmplification: target gene/SSTR2 ratio ≥2; deletion: target gene/SSTR2 ratio ≤0.5; normal: 0.5 < target gene/SSTR2 ratio <2. MED1, mediator complex subunit 1 gene; STARD3, steroidogenic acute regulatory-related lipid transfer (START) domain containing 3 gene; HER2, human epidermal growth factor receptor 2 gene; GRB7, growth factor receptor-bound protein 7 gene; THRA, thyroid hormone receptor α gene; RARA, retinoic acid receptor α gene; TOP2A, topoisomerase IIα gene; IGFBP4, insulin-like growth factor-binding protein 4 gene; CCR7, C-C chemokine receptor type 7 gene; KRT20, cytokeratin 20 gene; KRT19, cytokeratin 19 gene; GAS, gastrin gene; SSTR2, somatostatin receptor type II gene.

Back to article page

ISSN: 1465-542X

Contact us

Submission enquiries: journalsubmissions@springernature.com

Breast Cancer Research

Contact us