PRL-induced adenocarcinomas display molecular features of luminal clinical breast tumors. (a-d) RNA from mammary carcinomas that developed in NRL-PRL, MMTV-neu , C3(1)-SV40 Tag , and transplanted p53-/- (O'Leary and Schuler, manuscript in preparation) models was examined for levels of transcripts comprising the luminal signature  by qRT-PCR as described in the Materials and Methods. PRL-induced papillary adenocarcinomas were of diverse ERα status by IHC. Each symbol denotes a distinct tumor. The horizontal bar indicates the mean level for each model.