Study scale | Single genes | Whole pathwaysb | Whole exomec |
---|
Type I error | 0.05 | 0.0005 | 2.5 × 10-6 |
Power | 0.80 | 0.80 | 0.80 |
rMS alone, n | 1,975 | 4,700 | 7,725 |
T+SJV alone, n | 1,425 | 3,400 | 5,600 |
rMS plus T+SJV, n | 850 | 2,025 | 3,350 |
- a rMS, rare missense substitution; T+SJV, protein-truncating variants plus splice junction variant; b Calculated for 100 genes, approximately the gene count of DNA double-stranded break repair and associated cell cycle checkpoints; cCalculated for 20,000 genes.