Table 3 Analyses of rare variants with missense substitutions stratified by Align-GVGD grade^a

Noncarriers

1,242

1,089

T+SJV

17

3

4.97 (1.45 to 17.0)

6.18 (1.76 to 21.8)

Any rMS

44

17

2.27 (1.29 to 4.00)

2.20 (1.20 to 4.01)

rMS stratified by Align-GVGD grade^b

   C0

12

9

1.17 (0.49 to 2.79)

1.39 (0.55 to 3.56)

   C15

14

5

2.46 (0.88 to 6.84)

1.82 (0.62 to 5.34)

   C25

7

2

3.07 (0.64 to 14.8)

2.47 (0.45 to 13.49)

   C35

1

0

   -

   C45

0

0

   -

   C55

1

0

   -

   C65

9

1

7.89 (1.00 to 62.4)

8.75 (1.06 to 72.2)

rMS stratified by SIFT grade^c

   S > 0.05

21

8

2.30 (1.02 to 5.22)

1.99 (0.83 to 4.77)

   0.05 ≥ S > 0.00

12

5

2.10 (0.74 to 5.99)

1.91 (0.63 to 5.86)

   S = 0.00

11

4

2.41 (0.77 to 7.59)

3.03 (0.91 to 10.0)

rMS stratified by PolyPhen-2 grade

   Benign

16

7

2.00 (0.82 to 4.89)

1.69 (0.64 to 4.41)

   Possibly D^d

10

6

1.46 (0.53 to 4.03)

1.65 (0.55 to 4.89)

   Probably D^e

18

4

3.95 (1.33 to 11.7)

3.87 (1.25 to 12.0)