Pedigrees of the PALB2 c.3113G > A mutation-carrying families. Pedigrees of the PALB2 c.3113G > A mutation carrying families with (a) probands (indicated by arrows) and (b) families with probands diagnosed under the age of 40 years identified in the population-based study. (c) Family with probands diagnosed under the age of 50 years and (d) families diagnosed under the age of 60 years. Breast cancer is indicated by black filled symbols, and other cancers are indicated by gray filled symbols. All primary cancer diagnoses are indicated for each individual. Numbers within symbols represent multiple individuals. Breast, breast cancer; V, cancer verified; +, PALB2 c.3113G > A-positive; -, PALB2 c.3113G > A-negative; (+), obligate carrier;/, deceased.