Univariate analysis | Multivariate analysisa | ||||||||
---|---|---|---|---|---|---|---|---|---|
Factor | Number | HR | 95% CI | Pvalue | HR | 95% CI | Pvalue | ||
837 | |||||||||
Age, years | |||||||||
≤ 40 | 114 | 1 | 1 | ||||||
41-55 | 295 | 0.88 | 0.63 | 1.22 | 0.95 | 0.67 | 1.35 | ||
56-70 | 270 | 0.72 | 0.51 | 1.02 | 0.69 | 0.40 | 1.20 | ||
>70 | 158 | 0.53 | 0.35 | 0.81 | < 0.01 | 0.49 | 0.27 | 0.90 | 0.077 |
Menopausal status | |||||||||
Premenopausal | 350 | 1 | 1 | ||||||
Postmenopausal | 487 | 0.78 | 0.62 | 0.97 | 0.028 | 1.08 | 0.70 | 1.66 | 0.731 |
Grade | |||||||||
Poor | 422 | 1 | 1 | ||||||
Unknown | 262 | 1.02 | 0.79 | 1.30 | 1.12 | 0.87 | 1.44 | ||
Moderate and good | 153 | 0.49 | 0.34 | 0.71 | < 0.001 | 0.54 | 0.37 | 0.78 | < 0.001 |
PGR mRNA statusb | |||||||||
Negative, < 0.1 | 312 | 1 | 1 | ||||||
Positive, ≥0.1 | 525 | 0.68 | 0.54 | 0.85 | 0.001 | 0.71 | 0.53 | 0.95 | 0.022 |
Tumor size | |||||||||
≤ 2 cm | 378 | 1 | |||||||
>2 cm + unknown | 459 | 1.26 | 1.00 | 1.59 | 0.047 | Analyses stratified by tumor size to meet the proportional hazards assumption | |||
ESR1 mRNA statusb | |||||||||
Negative, < 0.2 | 199 | 1 | |||||||
Positive, ≥0.2 | 638 | 0.77 | 0.59 | 0.99 | 0.040 | ||||
Factor analyzed | Additions to the base model | ||||||||
DC-SCRIPT | |||||||||
Continuous | 837 | 0.77 | 0.67 | 0.88 | < 0.001 | 0.80 | 0.70 | 0.92 | 0.001 |
33.3% low | 277 | 1 | 1 | ||||||
66.7% high | 560 | 0.55 | 0.43 | 0.69 | < 0.001 | 0.60 | 0.47 | 0.76 | < 0.001 |
ESR2 mRNA statusb | |||||||||
Continuous | 820 | 0.88 | 0.79 | 0.99 | 0.034 | 0.86 | 0.76 | 0.96 | 0.011 |
Dichotomized low, < 0.005 | 410 | 1 | 1.00 | ||||||
Dichotomized high, ≥0.005 | 410 | 0.80 | 0.63 | 1.00 | 0.052 | 0.75 | 0.59 | 0.94 | 0.014 |
DC-SCRIPT and ESR2 combined | |||||||||
Both low | 183 | 1 | 1 | ||||||
DC-SCRIPT low, ESR2 high | 91 | 0.74 | 0.51 | 1.08 | 0.71 | 0.49 | 1.04 | ||
DC-SCRIPT high, ESR2 low | 227 | 0.49 | 0.36 | 0.67 | 0.55 | 0.40 | 0.76 | ||
Both high | 319 | 0.50 | 0.38 | 0.67 | < 0.001 | 0.52 | 0.39 | 0.69 | < 0.001 |