Figure 2
From: Akt is required for Stat5 activation and mammary differentiation
Akt1-/-; Akt2+/- mice exhibit defective expansion of mammary gland during late pregnancy and lactation. (a) Whole-mount carmine-stained mammary glands from Akt1+/+;Akt2+/+ mice, Akt1-/-;Akt2+/+ mice, Akt1-/-;Akt2+/- mice, Akt1+/+;Akt2-/- mice, and Akt1+/-;Akt2-/- mice at day 18.5 of pregnancy and days 2 and 9 of lactation. (b) H & E-stained sections of mammary glands from mice with indicated Akt genotypes at day 18.5 of pregnancy (top) and day 9 of lactation (bottom). Scale bars: (a) 2 mm, (b) 100 μm.