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Figure 4 | Breast Cancer Research

Figure 4

From: Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations

Figure 4

Immunohistochemical analysis of the whole panel of breast tumors. Sections of three breast tumors occurring in patients with Cowden disease showing negative staining for PTEN (B, F, J), positive staining scored 2 for GCDFP15 (C) and GGT1 (D), positive staining scored 1 for GCDFP15 (G) and GGT1 (H) and negative staining for GCDFP15 (K) and GGT1 (L). The proportion of tumors showing positive staining for these proteins in Cowden tumors (n = 15), molecular apocrine tumors (n = 5) and the remaining familial breast cancers (n = 69) is shown in (M to O). See material and methods for attribution of scores 0, 1 and 2.

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