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Table 4 Association of Msx2 with cell cycle-associated and Msx2-interacting genes at the mRNA level within the Van de Vijver dataseta

From: Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro

Variable Van de Vivjer data set (n= 295)  
  Low Msx2
(n= 74)
High Msx2
(n= 221)
P value Association with
Prognosis?
Survivin    <0.001 Poor**
   Low 24 (32.4) 125 (56.6)   
   High 50 (67.6) 96 (43.4)   
Cyclin D1    <0.001 NS
Low
High
32 (43.2)
42 (56.8)
42 (19)
179 (81)
  
Cyclin A1    0.037 Poor**
   Low 49 (66.2) 173 (78.3)   
   High 25 (33.8) 48 (21.7)   
Cyclin A2    0.007 Poor**
   Low 27 (36.5) 121 (54.8)   
   High 47 (63.5) 100 (45.2)   
Cyclin B2    0.014 Poor**
   Low 28 (37.8) 120 (54.3)   
   High 46 (62.2) 101 (45.7)   
Cyclin E1    0.003 Poor**
   Low 46 (62.2) 175 (79.5)   
   High 28 (37.8) 45 (20.5)   
DLX5    0.077 Poor*
   Low 50 (67.6) 172 (77.8)   
   High 24 (32.4) 49 (22.2)   
BMP4    0.017 Good**
   Low 46 (62.2) 102 (46.2)   
   High 28 (37.8) 119 (53.8)   
  1. aBMP, bone morphogenetic protein; DLX5, distal-less homeobox 5; *P < 0.05 **P < 0.01 (log rank test); otherwise χ2 test.