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Table 2 Peak parametric multipoint LOD scores under heterogeneity, at three chromosomal regions as defined by family-70234 haplotypes

From: Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families

   6q15 to q22.31 14q21.2 to q24.3 2p23.2 to p21
Subset Number of families* HLOD α cM from D6S434 Number of linked families HLOD α cM from D14S980 Number of linked families HLOD α cM from D2S367 Number of linked families
Icelandic 12 2.02 0.45 -5.4 3 1.24 0.36 30.2 4 2.13 0.61 0.0 7
Lund/Oslo 3 1.37 0.79 0.3 2 0    0 0.46 1.00 -14.4 0
Helsinki 7 0.34 0.39 12.2 3 0.06 0.34 22.2 0 1.09 1.00 -13.1 2
Oulu 3 1.15 1.00 -1.9 2 0    0 0.75 1.00 -7.5 1
Total 25 3.27 0.40 0.0 10 1.24 0.36 30.2 4 1.66 0.25 0.0 10
  1. *Three Icelandic pedigrees were separated in two parts each in the linkage calculations. Therefore the total number of families in this table is 25.
  2. For each locus, the distance relates to the marker closest to the LOD-peak in family 70234; negative numbers refer to the direction towards the p-telomere.
  3. Linked families are defined as having a conditional probability of linked type (data not shown) exceeding the alpha for all families combined.