Table 2 Peak parametric multipoint LOD scores under heterogeneity, at three chromosomal regions as defined by family-70234 haplotypes
From: Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families
6q15 to q22.31 | 14q21.2 to q24.3 | 2p23.2 to p21 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subset | Number of families* | HLOD | α | cM from D6S434† | Number of linked families‡ | HLOD | α | cM from D14S980† | Number of linked families‡ | HLOD | α | cM from D2S367† | Number of linked families‡ |
Icelandic | 12 | 2.02 | 0.45 | -5.4 | 3 | 1.24 | 0.36 | 30.2 | 4 | 2.13 | 0.61 | 0.0 | 7 |
Lund/Oslo | 3 | 1.37 | 0.79 | 0.3 | 2 | 0 | 0 | 0.46 | 1.00 | -14.4 | 0 | ||
Helsinki | 7 | 0.34 | 0.39 | 12.2 | 3 | 0.06 | 0.34 | 22.2 | 0 | 1.09 | 1.00 | -13.1 | 2 |
Oulu | 3 | 1.15 | 1.00 | -1.9 | 2 | 0 | 0 | 0.75 | 1.00 | -7.5 | 1 | ||
Total | 25 | 3.27 | 0.40 | 0.0 | 10 | 1.24 | 0.36 | 30.2 | 4 | 1.66 | 0.25 | 0.0 | 10 |