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Table 1 Inter-observer and intra-observer agreement of breast cancer histological grade.

From: Breast cancer prognostic classification in the molecular era: the role of histological grade

Study Number of cases Number of readers Grade Inter-observer
[32] 613 2 NGS Kappa 0.69
[8] 52 2 NGS Kappa 0.54
[55] 425 2 NGS Complete agreement 76%
[50] 75 6 NGS Kappa 0.43 to 0.74
[51] 12 600 NGS Kappa 0.45 to 0.53 (figures after application of guidelines)
[52]   3 NGS Complete agreement 72.3%; kappa 0.57
[53] 24 21 NGS Complete agreement 69%; kappa 0.53
[54] 50 5 NGS Mean polychoric correlation 0.8
[56] 35 13 NGS Kappa 0.5 to 0.7
[57] 93 7 NGS Kappa 0.54
[58] 40 3 NGS Kappa 0.68 to 0.83
[59] 874 2 WHO criteria Complete agreement 78.1%; kappa 0.66
[61] 50 5 NGS Complete agreement 83.3%; kappa 0.73
  1. NGS, Nottingham Grading System; WHO, World Health Organization.