Figure 4
From: Incorporating tumour pathology information into breast cancer risk prediction algorithms
Influence of tumour pathology on mutation carrier probabilities for a single affected individual. Mutation carrier probabilities for a single affected individual with no knowledge of family history of breast cancer: BRCA1 carrier probabilities are shown in relation to (a) oestrogen receptor (ER) status, (b) tumour-negative (TN) status, when the tumour is known to be ER-negative, and (c) cytokeratin (CK)5/6 and/or CK14 expression when the tumour is known to be TN. In (c) scenarios where both basal markers have been tested (**) or where only CK5/6 has been tested (*) are shown. BRCA2 carrier probabilities are shown in relation to (d) TN status when the tumour is known to be ER-negative.