Gene/Clinical | Comparison | Unadjusted DFS | Unadjusted OS | ||
---|---|---|---|---|---|
 |  | HR (95% CI) | Wald P-value | HR (95% CI) | Wald P-value |
CYP2B6 | Any variant vs. All WT | 1.10 (0.83, 1.46) | 0.51 | 1.12 (0.83, 1.52) | 0.46 |
CYP2C9 | Any variant vs. All WT | 0.97 (0.72, 1.29) | 0.82 | 1.01 (0.75, 1.37) | 0.94 |
CYP2D6 | G/A vs. A/A | 1.07 (0.57, 2.03) | 0.83 | 1.30 (0.64, 2.62) | 0.46 |
 | G/G vs. A/A | 0.89 (0.48, 1.65) | 0.72 | 1.01 (0.51, 1.99) | 0.98 |
CYP3A4 | *1B/*1A vs. *1A/*1A | 1.70 (1.10, 2.63) | 0.02 | 1.21 (0.74, 1.96) | 0.45 |
 | *1B/*1B vs *1A/*1A | 1.96 (0.96, 3.98) | 0.07 | 1.64 (0.77, 3.50) | 0.20 |
CYP3A5 | *3/*1 vs. *1/*1 | 0.76 (0.36, 1.59) | 0.47 | 1.18 (0.49, 2.84) | 0.72 |
 | *3/*3 vs. *1/*1 | 0.74 (0.38, 1.45) | 0.38 | 1.18 (0.52, 2.67) | 0.69 |
CYP3A5 | *6/*1 vs. *1/*1 | 2.71 (1.01, 7.32) | 0.05 | 2.47 (0.92, 6.66) | 0.07 |
GSTM1 | Null vs. Non-null | 0.71 (0.54, 0.93) | 0.02 | 0.71 (0.53, 0.94) | 0.02 |
GSTT1 | Null vs. Non-null | 1.41 (1.00, 1.97) | 0.05 | 1.31 (0.91, 1.88) | 0.14 |
GSTP1 | Any Var vs. All WT | 1.03 (0.79, 1.36) | 0.81 | 1.18 (0.88, 1.57) | 0.27 |
CYP-GST genotype groups | Unfavorable vs. Intermediate or Favorable | 1.29 (0.97-1.72) | 0.08 | 1.32 (0.98-1.79) | 0.07 |
Lymph node | Continuous | 1.02 (1.00, 1.04) | 0.06 | 1.02 (1.00, 1.04) | 0.10 |
Tumor size | Continuous | 1.00 (1.00, 1.01) | 0.36 | 1.00 (1.00, 1.01) | 0.13 |
Age | Continuous | 0.99 (0.97, 1.00) | 0.10 | 0.99 (0.97, 1.01) | 0.28 |
ER | Pos vs. Neg | 0.79 (0.60, 1.04) | 0.10 | 0.78 (0.58, 1.04) | 0.10 |
PR | Pos vs. Neg | 0.82 (0.62, 1.07) | 0.15 | 0.88 (0.66, 1.17) | 0.37 |
Race | Black vs. White | 1.44 (0.84, 2.48) | 0.19 | 1.41 (0.80, 2.49) | 0.23 |
 | Other vs. White | 1.49 (0.83, 2.68) | 0.18 | 1.20 (0.64, 2.28) | 0.57 |
Arm | CAF+HDC vs. CAF | 0.79 (0.60, 1.03) | 0.08 | 0.93 (0.70, 1.23) | 0.59 |