Figure 2

Comparison of gene expression profiles of normal mouse mammary cell subsets with mammary tumor models. (a) Box plots of signature expression scores by the mouse mammary tumor model for each subset. The MaSC-enriched signature scores are highest in the MMTV-Wnt-1 and p53^-/- tumors, whereas the luminal progenitor signature scores are highest in the MMTV-Neu and MMTV-PyMT models. *P < 0.05, **P < 0.01, ***P < 0.001. Mammary tumor datasets are from Herschkowitz et al. [14]. (b) Schematic model of the mouse mammary epithelial hierarchy and possible relations with mouse mammary tumor models. Subpopulations containing MaSCs, luminal progenitor, and mature luminal cells are defined by differential expression of CD24, CD29, and CD61. Gene expression profiling of these subpopulations revealed similarities to specific mouse mammary tumor models, depicted on the right side.