Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers

Table 3 Correlation matrix of histopathologic variables and expression of each signaling protein

	≥ T3	LN+	Grade 3	ER	HER2	Ki-67	PTEN	PI3K-p110α	p-Akt	p-p70S6K	p-S6	p-Raf	p-p44/42-MAPK
≥ T3	-
LN+	0.010	-
Grade 3	0.044	0.185	-
ER	0.100	0.772	< 0.001	-
HER2	0.361	0.042	< 0.001	< 0.001	-
Ki-67	0.821	0.236	< 0.001	< 0.001	< 0.001	-
PTEN	0.746	0.644	0.015	0.042	0.753	0.031	-
PI3K-p110α	0.151	0.770	0.236	0.159	0.085	0.768	0.552	-
p-Akt	0.668	0.762	0.006	0.702	< 0.001	0.060	0.284	0.211	-
p-p70S6K	0.925	0.139	0.035	< 0.001	< 0.001	0.057	0.780	0.192	0.002	-
p-S6	0.930	0.606	< 0.001	< 0.001	0.004	< 0.001	0.172	0.553	0.011	< 0.001	-
p-Raf	0.974	0.671	0.509	0.770	0.328	0.800	0.343	0.266	< 0.001	< 0.001	0.364	-
p-p44/42 MAPK	0.756	0.562	0.238	0.623	0.841	0.118	0.428	0.334	0.147	0.015	0.974	< 0.001	-
HSP90	0.302	0.510	0.588	0.178	0.471	0.759	0.481	0.065	0.062	0.153	0.208	0.047	0.278

Variables found to be significant (P < 0.05) are shown in bold. ER = estrogen receptor; HER2 = human epidermal growth factor receptor-2; HSP90 = heat-shock protein 90; MAPK = mitogen-activated protein kinase; PI3K = phosphatidylinositol-3-kinase; PTEN = phosphatase and tensin homologue deleted on chromosome 10.

ISSN: 1465-542X