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Table 3 Correlation matrix of histopathologic variables and expression of each signaling protein

From: Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers

  ≥ T3 LN+ Grade 3 ER HER2 Ki-67 PTEN PI3K-p110α p-Akt p-p70S6K p-S6 p-Raf p-p44/42-MAPK
≥ T3 -             
LN+ 0.010 -            
Grade 3 0.044 0.185 -           
ER 0.100 0.772 < 0.001 -          
HER2 0.361 0.042 < 0.001 < 0.001 -         
Ki-67 0.821 0.236 < 0.001 < 0.001 < 0.001 -        
PTEN 0.746 0.644 0.015 0.042 0.753 0.031 -       
PI3K-p110α 0.151 0.770 0.236 0.159 0.085 0.768 0.552 -      
p-Akt 0.668 0.762 0.006 0.702 < 0.001 0.060 0.284 0.211 -     
p-p70S6K 0.925 0.139 0.035 < 0.001 < 0.001 0.057 0.780 0.192 0.002 -    
p-S6 0.930 0.606 < 0.001 < 0.001 0.004 < 0.001 0.172 0.553 0.011 < 0.001 -   
p-Raf 0.974 0.671 0.509 0.770 0.328 0.800 0.343 0.266 < 0.001 < 0.001 0.364 -  
p-p44/42 MAPK 0.756 0.562 0.238 0.623 0.841 0.118 0.428 0.334 0.147 0.015 0.974 < 0.001 -
HSP90 0.302 0.510 0.588 0.178 0.471 0.759 0.481 0.065 0.062 0.153 0.208 0.047 0.278
  1. Variables found to be significant (P < 0.05) are shown in bold. ER = estrogen receptor; HER2 = human epidermal growth factor receptor-2; HSP90 = heat-shock protein 90; MAPK = mitogen-activated protein kinase; PI3K = phosphatidylinositol-3-kinase; PTEN = phosphatase and tensin homologue deleted on chromosome 10.