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Table 2 Enzyme-prodrug systems under investigation for genetic prodrug activation therapy applications

From: Gene therapy for carcinoma of the breast: Genetic toxins

Enzyme Prodrug Cytotoxic product
Herpes simplex virus thymidine kinase Ganciclovir Ganciclovir triphosphate
Cytosine deaminase 5-Fluorocytosine 5-Fluorouracil
Varicella zoster virus thymidine kinase 6-Methoxypurine arabinose Adenine arabinonucleoside triphosphate
Nitroreductase CB1954 5-Aziridinyl-4-hydroxylamino-2-nitrobenzamide
Cytochrome p450 Cyclophosphamide Acrolein and phosphoramide mustard
Thymidine phosphorylase 5' -Deoxy-5-fluorouridine 5-Fluorouracil
Purine nucleoside phosphorylase 6-Methylpurine-deoxyriboside 6-Methylpurine
Alkaline phosphatase Etoposide phosphate Etoposide
Carboxypeptidase A Methotrexate-alanine Methotrexate
Carboxypeptidase G2 Benzoic acid mustard-glucuronide Benzoic acid mustard
Linamarase Linamarin Cyanide
Xanthine oxidase Xanthine Oxygen radicals
β -Lactamase Cephalosporin-mustard-carbamate Nitrogen mustard