Prescriptions for selective cyclooxygenase-2 inhibitors, non-selective non-steroidal anti-inflammatory drugs, and risk of breast cancer in a population-based case-control study

Table 2 Temporality of non-steroidal anti-inflammatory drug use and odds ratio of breast cancer

Characteristics	Cases* (N = 8,195)		Controls* (N = 81,950)		Odds Ratio^	95% Confidence Interval
	N	%	N	%
Any NSAID use
Ever versus never					1.04	0.99 to 1.10
Never/rare¹	5,353	65	54,742	67	1.00
Recent use²	1,147	14	11,236	14	1.00	0.93 to 1.08
Former use³	1,695	21	15,972	20	1.02	0.96 to 1.09
Selective Cox-2 Inhibitors
Ever versus never					1.08	0.99 to 1.18
Never/rare¹	6,361	78	64,549	79	1.00
Recent use²	442	5	4,105	5	0.98	0.84 to 1.15
Former use³	1,392	17	13,296	16	1.12	1.02 to 1.24
Non-selective Non-aspirin
Non-Steroidal Anti-Inflammatory Drugs
Ever versus never					1.04	0.98 to 1.10
Never/rare¹	7,494	91	75,636	92	1.00
Recent use²	184	2	1,812	2	1.06	0.95 to 1.17
Former use³	517	6	4,502	6	1.03	0.97 to 1.10
Aspirin
Ever versus never
Never/rare¹	7,396	90	73,947	90	0.98	0.90 to 1.07
Recent use²	548	7	5,596	7	0.96	0.87 to 1.06
Former use³	251	3	2,407	3	1.02	0.89 to 1.17

* Matched on county of residence and birth year. ^Analyses adjusted for use of hormone replacement therapy, rheumatoid arthritis and migraine. ¹ Never/rare use: <3 prescriptions in total. ² Recent use: >2 prescriptions within two years of diagnosis. ³ Former use, </= 2 prescriptions within two years of diagnosis. NSAIDs, non-steroidal anti-inflammatory drugs.

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