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Table 2 Temporality of non-steroidal anti-inflammatory drug use and odds ratio of breast cancer

From: Prescriptions for selective cyclooxygenase-2 inhibitors, non-selective non-steroidal anti-inflammatory drugs, and risk of breast cancer in a population-based case-control study

Characteristics Cases* (N = 8,195) Controls* (N = 81,950) Odds Ratio^ 95% Confidence Interval
  N % N %   
Any NSAID use       
Ever versus never      1.04 0.99 to 1.10
   Never/rare1 5,353 65 54,742 67 1.00  
   Recent use2 1,147 14 11,236 14 1.00 0.93 to 1.08
   Former use3 1,695 21 15,972 20 1.02 0.96 to 1.09
Selective Cox-2 Inhibitors       
Ever versus never      1.08 0.99 to 1.18
   Never/rare1 6,361 78 64,549 79 1.00  
   Recent use2 442 5 4,105 5 0.98 0.84 to 1.15
   Former use3 1,392 17 13,296 16 1.12 1.02 to 1.24
Non-selective Non-aspirin       
Non-Steroidal Anti-Inflammatory Drugs       
Ever versus never      1.04 0.98 to 1.10
   Never/rare1 7,494 91 75,636 92 1.00  
   Recent use2 184 2 1,812 2 1.06 0.95 to 1.17
   Former use3 517 6 4,502 6 1.03 0.97 to 1.10
Aspirin       
Ever versus never       
   Never/rare1 7,396 90 73,947 90 0.98 0.90 to 1.07
   Recent use2 548 7 5,596 7 0.96 0.87 to 1.06
   Former use3 251 3 2,407 3 1.02 0.89 to 1.17
  1. * Matched on county of residence and birth year. ^Analyses adjusted for use of hormone replacement therapy, rheumatoid arthritis and migraine. 1 Never/rare use: <3 prescriptions in total. 2 Recent use: >2 prescriptions within two years of diagnosis. 3 Former use, </= 2 prescriptions within two years of diagnosis. NSAIDs, non-steroidal anti-inflammatory drugs.
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