Skip to main content

Advertisement

Table 4 Familial relative risk for breast cancer by marker status of index case tumour and age of relative *

From: Familial relative risks for breast cancer by pathological subtype: a population-based cohort study

Phenotype Age of relative (years)* OBS EXP FRR 95%CI
PR-positive      
  <50 60 29.46 2.04 1.52 to 2.55
  50 to 84 187 102.77 1.82 1.55 to 2.10
  0 to 84 247 132.23 1.87 1.63 to 2.11
PR-negative      
  <50 46 13.39 3.44 2.37 to 4.50
  50 to 84 65 46.00 1.41 1.06 to 1.76
  0 to 84 111 59.39 1.87 1.55 to 2.24
HER2-positive      
  <50 11 4.17 2.64 1.08 to 4.20
  50 to 84 25 13.70 1.83 1.08 to 2.57
  0 to 84 36 17.86 2.02 1.34 to 2.69
HER2-negative      
  <50 65 28.50 2.28 1.73 to 2.86
  50 to 84 154 100.77 1.53 1.28 to 1.77
  0 to 84 219 129.27 1.69 1.46 to 1.92
ER+PR+      
  <50 55 27.20 2.02 1.49 to 2.56
  50 to 84 173 95.89 1.80 1.52 to 2.08
  0 to 84 228 123.10 1.85 1.60 to 2.10
ER-PR+      
  <50 5 1.91 2.62 0.33 to 4.91
  50 to 84 12 5.74 2.09 0.84 to 3.35
  0 to 84 17 7.64 2.22 1.16 to 3.32
ER+PR-      
  <50 15 4.13 3.63 1.85 to 5.41
  50 to 84 24 16.31 1.47 0.88 to 2.06
  0 to 84 39 20.44 1.91 1.31 to 2.51
ER or PR+ (luminal)      
  <50 140 68.04 2.06 1.71 to 2.40
  50 to 84 437 247.27 1.77 1.61 to 1.94
  0 to 84 577 315.30 1.83 1.68 to 1.98
ER or PR+ HER2+ (luminal HER2+)      
  <50 6 2.68 2.24 0.48 to 4.00
  50 to 84 16 8.35 1.92 0.94 to 2.90
  0 to 84 22 11.03 2.00 1.15 to 2.84
ER or PR+ HER2- (luminal HER2-)      
  <50 53 23.49 2.26 1.65 to 2.87
  50 to 84 136 85.67 1.59 1.32 to 1.86
  0 to 84 189 109.15 1.73 1.48 to 2.00
ER-PR- (non-luminal)      
  <50 31 9.17 3.38 2.05 to 4.72
  50 to 84 41 29.10 1.41 0.97 to 1.85
  0 to 84 72 38.26 1.88 1.41 to 2.35
ER-PR-HER2+ (non-luminal HER2+)      
  <50 4 1.25 3.20 1.20 to 8.85
  50 to 84 6 4.52 1.33 0.35 to 2.29
  0 to 84 10 5.77 1.73 0.61 to 2.86
ER-PR-HER2- (TN)      
  <50 9 4.12 2.18 0.77 to 3.59
  50 to 84 15 12.55 1.20 0.60 to 1.79
  0 to 84 24 16.67 1.44 0.85 to 2.03
  1. CI: confidence interval; ER: estrogen receptor; EXP: expected; FRR: familial relative risk; HER2: human epidermal growth factor receptor 2; PR: progesterone receptor; OBS: observed; TN: triple negative.
  2. * <50: relatives were followed up from birth up until censoring or age 50, whichever occurred first, 50-84: from age 50 to censoring, 0-85: from birth to censoring