Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer

Table 1 Correlation of expression of PIPKIγ protein with different biomarkers

Biomarker	PIPKIγ negative and weak vs. strong staining
	Spearman's correlation coefficient	Pvalue	Number of cases
E-cadherin negative vs. weak and strong staining	0.106	0.046	351
ER at 1% cut-off point	-0.256	0.000003	327
PR at 1% cut-off point	-0.298	0.000001	256
EGFR (HER1) negative vs. weak and strong staining	0.262	0.000003	306
HER2/neu	0.171	0.003	309
Nottingham Grade	0.185	0.001	346
Tumour size	0.025	0.648	349
Nodal status	0.012	0.828	314

EGFR = epidermal growth factor receptor; ER = estrogen receptor; HER2 = human epidermal growth factor receptor 2; PIPKIγ = type I gamma phosphatidylinositol phosphate kinase; PR = progesterone receptor.

ISSN: 1465-542X