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Figure 7 | Breast Cancer Research

Figure 7

From: Dynamic regulation of CD24 and the invasive, CD44posCD24negphenotype in breast cancer cell lines

Figure 7

Dynamic regulation of CD24 and the invasive CD44posCD24neg phenotype. Schematic representation of the plasticity of the CD44posCD24neg, invasive/mesenchymal phenotype. Inhibition of Activin/Nodal signaling blocks the ability of CD44posCD24pos cells to give rise to invasive, mesenchymal progeny and CD44posCD24neg cells are prevented from giving rise to non-invasive, epithelial progeny. Depletion of CD24 via siRNA causes increased invasiveness without yielding a mesenchymal phenotype.

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