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Table 6 Breast cancer risk according to MRI absolute dense volume and Cumulus and visual assessment absolute dense areas (Medial-Lateral Oblique view), by BRCA1/BRCA2 genetic status

From: Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study

  No. women No. cancers No. pyears IRR (95% CI) P-value (adjusted age) IRR (95% CI) P-value (adjusted age, BMI & parity)
BRCA1 Carriers
MRI dense volume 117 21 687 3.62 (1.32, 9.90) 0.012 3.10 (0.95, 10.1) 0.060
Cumulus MLO dense area 94 16 579 1.54 (0.58, 4.10) 0.39 1.27 (0.39, 4.11) 0.69
BRCA2 Carriers
MRI dense volume 69 18 385 3.06 (1.14, 8.19) 0.026 6.75 (1.80, 25.2) 0.005
Cumulus MLO dense area 71 15 418 1.03 (0.34, 3.10) 0.96 1.44 (0.38, 5.47) 0.59
Non-Carriers
MRI dense volume 357 14 2,495 1.27 (0.44, 3.65) 0.66 0.79 (0.24, 2.67) 0.71
Cumulus MLO dense area 332 7 2,367 1.14 (0.25, 5.11) 0.87 0.58 (0.11, 3.06) 0.52
  1. The non-carrier group includes those who tested negative for a known BRCA1/2 family mutation as well as those in whom no mutation was detected after a BRCA1/2 mutation screen, because of the small numbers.
  2. Pyears = number of person-years in study and follow-up period
  3. IRR = incidence rate ratio, estimated for the upper two quartiles vs the lower two quartiles (the trend test was not attempted due to the small numbers)
  4. CI = confidence interval