| No. women | No. cancers | No. pyears | IRR (95% CI) P-value (adjusted age) | IRR (95% CI) P-value (adjusted age, BMI & parity) |
---|---|---|---|---|---|
BRCA1 Carriers | |||||
MRI % dense volume | 117 | 21 | 687 | 1.84 (0.77, 4.38) 0.17 | 1.02 (0.26, 4.05) 0.98 |
Cumulus MLO % dense area | 94 | 16 | 579 | 2.72 (0.99, 7.48) 0.053 | 1.24 (0.35, 4.37) 0.74 |
VA MLO % dense area | 94 | 16 | 579 | 4.03 (1.40, 11.6) 0.010 | 3.39 (0.94, 12.2) 0.062 |
BRCA2 Carriers | |||||
MRI % dense volume | 69 | 18 | 385 | 2.06 (0.78, 5.45) 0.15 | 3.10 (0.77, 12.4) 0.11 |
Cumulus MLO % dense area | 71 | 15 | 418 | 1.66 (0.60, 4.60) 0.33 | 10.4 (1.58, 68.0) 0.015 |
VA MLO % dense area | 71 | 15 | 418 | 1.75 (0.62, 4.90) 0.29 | 3.70 (0.64, 21.2) 0.14 |
Non-carriers | |||||
MRI % dense volume | 361 | 14 | 2,532 | 4.49 (1.16, 17.3) 0.030 | 2.54 (0.56, 11.6) 0.23 |
Cumulus MLO % dense area | 332 | 7 | 2,367 | 1.13 (0.25, 5.17) 0.87 | 0.24 (0.04, 1.45) 0.12 |
VA MLO % dense area | 327 | 7 | 2,336 | 1.45 (0.32, 6.66) 0.63 | 0.43 (0.08, 2.41) 0.34 |