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Table 1 Genotype distributions by patient and tumor characteristics

From: Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study

  

SIPA1 rs2448490

RRP1B rs9306160

  

GG

AG

AA

CC

CT

TT

Characteristic

Patients

n

(%)

n

(%)

n

(%)

n

(%)

n

(%)

n

(%)

Total

18631

748

(40)

807

(43)

293

(16)

616

(33)

904

(49)

333

(18)

Age (years)

             

   ≤40

239

98

(41)

98

(41)

43

(18)

82

(34)

123

(51)

34

(14)

   41-55

736

301

(41)

323

(44)

103

(14)

235

(32)

359

(49)

139

(19)

   56-70

597

228

(39)

265

(45)

98

(17)

193

(33)

285

(48)

114

(19)

   >70

291

121

(42)

121

(42)

49

(17)

106

(37)

137

(47)

46

(16)

  

P = 0.661

P = 0.481

Menopausal status

             

   Premenopausal

823

334

(41)

364

(45)

117

(14)

268

(33)

419

(51)

135

(16)

   Postmenopausal

1040

414

(40)

443

(43)

176

(17)

348

(34)

485

(47)

198

(19)

  

P = 0.288

P = 0.165

Lymph nodes involved

             

   0

1095

441

(41)

459

(42)

183

(17)

358

(33)

535

(49)

192

(18)

   1-3

350

134

(38)

165

(47)

50

(14)

107

(31)

180

(51)

63

(18)

   >3

418

173

(42)

183

(44)

60

(14)

151

(36)

189

(45)

78

(19)

  

P = 0.438

P = 0.459

Tumor size

             

   pT1

686

280

(41)

289

(43)

109

(16)

209

(31)

340

(50)

131

(19)

   pT2

977

390

(40)

435

(45)

148

(15)

333

(34)

461

(47)

180

(18)

   pT3/4

200

78

(40)

83

(42)

36

(18)

74

(37)

103

(52)

22

(11)

  

P = 0.789

P = 0.049

Grade

             

   Poor

1007

403

(40)

437

(44)

162

(16)

326

(33)

508

(51)

168

(17)

   Good/moderate

282

113

(41)

120

(43)

44

(16)

101

(36)

122

(44)

56

(20)

   Unknown

574

232

(41)

250

(44)

87

(15)

189

(33)

274

(48)

109

(19)

  

P = 0.994

P = 0.280

ER status

             

   Positive

1367

529

(39)

606

(45)

219

(16)

445

(33)

666

(49)

249

(18)

   Negative

487

217

(45)

194

(40)

74

(15)

169

(35)

233

(48)

82

(17)

  

P = 0.087

P = 0.625

PR status

             

   Positive

1149

442

(39)

521

(46)

174

(15)

369

(32)

563

(49)

212

(19)

   Negative

601

267

(45)

232

(39)

99

(17)

207

(35)

290

(49)

99

(17)

  

P = 0.018

P = 0.459

  1. 1Due to missing values the numbers do not always add up to 1863.
  2. 2All P values derived from Pearson's chi-squared statistics.
  3. xER = oestrogen receptor; PR = progesterone receptor.
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Breast Cancer Research

ISSN: 1465-542X

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