|  | SIPA1 rs2448490 | RRP1B rs9306160 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  | GG | AG | AA | CC | CT | TT | ||||||
Characteristic | Patients | n | (%) | n | (%) | n | (%) | n | (%) | n | (%) | n | (%) |
Total | 18631 | 748 | (40) | 807 | (43) | 293 | (16) | 616 | (33) | 904 | (49) | 333 | (18) |
Age (years) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   ≤40 | 239 | 98 | (41) | 98 | (41) | 43 | (18) | 82 | (34) | 123 | (51) | 34 | (14) |
   41-55 | 736 | 301 | (41) | 323 | (44) | 103 | (14) | 235 | (32) | 359 | (49) | 139 | (19) |
   56-70 | 597 | 228 | (39) | 265 | (45) | 98 | (17) | 193 | (33) | 285 | (48) | 114 | (19) |
   >70 | 291 | 121 | (42) | 121 | (42) | 49 | (17) | 106 | (37) | 137 | (47) | 46 | (16) |
 |  | P = 0.661 | P = 0.481 | ||||||||||
Menopausal status | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Premenopausal | 823 | 334 | (41) | 364 | (45) | 117 | (14) | 268 | (33) | 419 | (51) | 135 | (16) |
   Postmenopausal | 1040 | 414 | (40) | 443 | (43) | 176 | (17) | 348 | (34) | 485 | (47) | 198 | (19) |
 |  | P = 0.288 | P = 0.165 | ||||||||||
Lymph nodes involved | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   0 | 1095 | 441 | (41) | 459 | (42) | 183 | (17) | 358 | (33) | 535 | (49) | 192 | (18) |
   1-3 | 350 | 134 | (38) | 165 | (47) | 50 | (14) | 107 | (31) | 180 | (51) | 63 | (18) |
   >3 | 418 | 173 | (42) | 183 | (44) | 60 | (14) | 151 | (36) | 189 | (45) | 78 | (19) |
 |  | P = 0.438 | P = 0.459 | ||||||||||
Tumor size | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   pT1 | 686 | 280 | (41) | 289 | (43) | 109 | (16) | 209 | (31) | 340 | (50) | 131 | (19) |
   pT2 | 977 | 390 | (40) | 435 | (45) | 148 | (15) | 333 | (34) | 461 | (47) | 180 | (18) |
   pT3/4 | 200 | 78 | (40) | 83 | (42) | 36 | (18) | 74 | (37) | 103 | (52) | 22 | (11) |
 |  | P = 0.789 | P = 0.049 | ||||||||||
Grade | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Poor | 1007 | 403 | (40) | 437 | (44) | 162 | (16) | 326 | (33) | 508 | (51) | 168 | (17) |
   Good/moderate | 282 | 113 | (41) | 120 | (43) | 44 | (16) | 101 | (36) | 122 | (44) | 56 | (20) |
   Unknown | 574 | 232 | (41) | 250 | (44) | 87 | (15) | 189 | (33) | 274 | (48) | 109 | (19) |
 |  | P = 0.994 | P = 0.280 | ||||||||||
ER status | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Positive | 1367 | 529 | (39) | 606 | (45) | 219 | (16) | 445 | (33) | 666 | (49) | 249 | (18) |
   Negative | 487 | 217 | (45) | 194 | (40) | 74 | (15) | 169 | (35) | 233 | (48) | 82 | (17) |
 |  | P = 0.087 | P = 0.625 | ||||||||||
PR status | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Positive | 1149 | 442 | (39) | 521 | (46) | 174 | (15) | 369 | (32) | 563 | (49) | 212 | (19) |
   Negative | 601 | 267 | (45) | 232 | (39) | 99 | (17) | 207 | (35) | 290 | (49) | 99 | (17) |
 |  | P = 0.018 | P = 0.459 |