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Table 1 Muc4 expression in human breast tissue by immunohistochemistry with 1G8s. Tissue samples from normal breast tissue, primary tumors or lymph node metastases were assigned a value of 0 to 3+ based on their MUC4 staining intensity with 1G8s. Statistical analysis of MUC4 staining intensities is presented for individual samples (upper panel) and patient-matched samples (lower panel).

From: The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells

Tissue type - individual Number of cases (%)a Composite score (mean ± standard error) Pvalue Norm vs Prim Pvalue Prim vs Met
Normal 110 (92.4) 2.01 ± 0.09 < 0.001  
Hyperplastic 26 (100)    
Ductal carcinoma in situ 14 (85.7)    
Primary tumorb 264 (79.5) 1.30 ± 0.06   
Primary lobular carcinoma 22 (68.1)    
Metastasis 48 (84) 1.63 ± 0.15   0.033
Tissue type - paired Number of pairs Composite score (mean ± standard error) P values McNemar's test  
Normal with matched primary 73   < 0.001  
   Normal   2.07 ± 0.10   
   Primary   1.28 ± 0.12   
Primary with matched metastasisc 43   0.0025  
   Primary   1.10 ± 0.21   
   Metastasis   1.95 ± 0.41   
  1. a. Percent of patient samples that had 1+ stain or greater on a scale from 0 to 3+.
  2. b. Primarily consists of invasive ductal carcinoma-NOS, but also includes invasive lobular carcinoma, micropapillary and mucinous carcinomas.