| |
Quintiles of serum 25(OH)D concentration (nmol/L)
|
Pfor trend‡
|
|---|
| |
<36.7
|
36.7-<49.8
|
49.8-<60.8
|
60.8-<73.2
|
73.2+
| |
|---|
|
All cases (n)
|
89
|
115
|
99
|
118
|
95
| |
|
Controls (n)
|
104
|
102
|
105
|
102
|
103
| |
|
OR (95% CI)*
|
1.00 (-)
|
1.31 (0.88-1.94)
|
1.11 (0.74-1.66)
|
1.35 (0.91-2.01)
|
1.07 (0.71-1.61)
|
0.8
|
|
OR (95%CI)†
|
1.00 (-)
|
1.29 (0.86-1.94)
|
1.14 (0.75-1.72)
|
1.44 (0.96-2.18)
|
1.09 (0.70-1.68)
|
0.6
|
| |
Tertiles of serum 25(OH)D concentration (nmol/L)
|
P
for trend
‡
| | |
| |
<45.9
|
45.9-<64.2
|
64.2+
| | | |
|
ER+ cases (n)
|
102
|
120
|
120
| | | |
|
Controls (n)
|
177
|
160
|
179
| | | |
|
OR (95% CI)*
|
1.00 (-)
|
1.32 (0.94-1.87)
|
1.16 (0.82-1.63)
|
0.4
| | |
|
OR (95%CI)†
|
1.00 (-)
|
1.32 (0.93-1.88)
|
1.15 (0.80-1.65)
|
0.5
| | |
|
ER- cases (n)
|
17
|
16
|
16
| | | |
|
Controls (n)
|
177
|
160
|
179
| | | |
|
OR (95% CI)*
|
1.00 (-)
|
1.02 (0.49-2.12)
|
0.90 (0.44-1.87)
|
0.8
| | |
|
OR (95%CI)†
|
1.00 (-)
|
1.03 (0.48-2.19)
|
0.95 (0.43-2.06)
|
0.9
| | |
|
In situ
cases (n)
§
|
34
|
39
|
30
| | | |
|
Controls (n)
|
177
|
160
|
179
| | | |
|
OR (95% CI)*
|
1.00 (-)
|
1.29 (0.77-2.16)
|
0.89 (0.52-1.54)
|
0.7
| | |
|
OR (95%CI)†
|
1.00 (-)
|
1.23 (0.72-2.09)
|
0.87 (0.49-1.55)
|
0.7
| | |
|
Localized cases (n)
§
|
90
|
114
|
114
| | | |
|
Controls (n)
|
177
|
160
|
179
| | | |
|
OR (95% CI)*
|
1.00 (-)
|
1.44 (1.01-2.06)
|
1.25 (0.88-1.79)
|
0.2
| | |
|
OR (95%CI)†
|
1.00 (-)
|
1.45 (1.01-2.09)
|
1.30 (0.90-1.89)
|
0.2
| | |
|
Regional/Distant Cases (n)
§
|
35
|
25
|
28
| | | |
|
Controls (n)
|
177
|
160
|
179
| | | |
|
OR (95% CI)*
|
1.00 (-)
|
0.79 (0.45-1.38)
|
0.79 (0.46-1.37)
|
0.4
| | |
|
OR (95%CI)†
|
1.00 (-)
|
0.78 (0.43-1.41)
|
0.75 (0.41-1.37)
|
0.3
| | |
- * Unconditional logistic regression adjusted for birth year, year of blood draw, race, and season.
- † Unconditional logistic regression adjusted for birth year, year of blood draw, race, season, parity and age at first birth, body mass index at blood collection and weight change from age 18 years to blood collection.
- ‡ P value for trend is calculated using the median for each category and modeled as a continuous variable.
- § Definition of cases based on Surveillance Epidemiology and End Results (SEER) summary staging.
- 25(OH)D = 25-hydroxyvitamin D; CPS-II = Cancer Prevention Study-II; CI = confidence interval; ER = estrogen receptor; OR = odds ratio.
