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Table 2 Odds ratio (OR) and 95% confidence interval (CI) between 25(OH)D levels and breast cancer risk, CPS II Nutrition Cohort women

From: Serum 25-hydroxyvitamin D concentrations and postmenopausal breast cancer risk: a nested case control study in the Cancer Prevention Study-II Nutrition Cohort

  Quintiles of serum 25(OH)D concentration (nmol/L) Pfor trend‡
  <36.7 36.7-<49.8 49.8-<60.8 60.8-<73.2 73.2+  
All cases (n) 89 115 99 118 95  
Controls (n) 104 102 105 102 103  
OR (95% CI)* 1.00 (-) 1.31 (0.88-1.94) 1.11 (0.74-1.66) 1.35 (0.91-2.01) 1.07 (0.71-1.61) 0.8
OR (95%CI)† 1.00 (-) 1.29 (0.86-1.94) 1.14 (0.75-1.72) 1.44 (0.96-2.18) 1.09 (0.70-1.68) 0.6
  Tertiles of serum 25(OH)D concentration (nmol/L) P for trend ‡   
  <45.9 45.9-<64.2 64.2+    
ER+ cases (n) 102 120 120    
   Controls (n) 177 160 179    
   OR (95% CI)* 1.00 (-) 1.32 (0.94-1.87) 1.16 (0.82-1.63) 0.4   
   OR (95%CI)† 1.00 (-) 1.32 (0.93-1.88) 1.15 (0.80-1.65) 0.5   
ER- cases (n) 17 16 16    
   Controls (n) 177 160 179    
   OR (95% CI)* 1.00 (-) 1.02 (0.49-2.12) 0.90 (0.44-1.87) 0.8   
   OR (95%CI)† 1.00 (-) 1.03 (0.48-2.19) 0.95 (0.43-2.06) 0.9   
In situ cases (n) § 34 39 30    
   Controls (n) 177 160 179    
   OR (95% CI)* 1.00 (-) 1.29 (0.77-2.16) 0.89 (0.52-1.54) 0.7   
   OR (95%CI)† 1.00 (-) 1.23 (0.72-2.09) 0.87 (0.49-1.55) 0.7   
Localized cases (n) § 90 114 114    
   Controls (n) 177 160 179    
   OR (95% CI)* 1.00 (-) 1.44 (1.01-2.06) 1.25 (0.88-1.79) 0.2   
   OR (95%CI)† 1.00 (-) 1.45 (1.01-2.09) 1.30 (0.90-1.89) 0.2   
Regional/Distant Cases (n) § 35 25 28    
   Controls (n) 177 160 179    
   OR (95% CI)* 1.00 (-) 0.79 (0.45-1.38) 0.79 (0.46-1.37) 0.4   
   OR (95%CI)† 1.00 (-) 0.78 (0.43-1.41) 0.75 (0.41-1.37) 0.3   
  1. * Unconditional logistic regression adjusted for birth year, year of blood draw, race, and season.
  2. † Unconditional logistic regression adjusted for birth year, year of blood draw, race, season, parity and age at first birth, body mass index at blood collection and weight change from age 18 years to blood collection.
  3. ‡ P value for trend is calculated using the median for each category and modeled as a continuous variable.
  4. § Definition of cases based on Surveillance Epidemiology and End Results (SEER) summary staging.
  5. 25(OH)D = 25-hydroxyvitamin D; CPS-II = Cancer Prevention Study-II; CI = confidence interval; ER = estrogen receptor; OR = odds ratio.
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