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Table 1 Clinical data of patients

From: Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells

  Total CTC-positive P value Total DTC-positive P value
Total 431 58 (13) 414 107 (24)   
Tumor size       
   pT1 285 34 (12) 0.47 274 66 (24) 0.07
   pT2 to pT4* 134 21 (16) 130 40 (31)   
   bilateral 10 2 (20) 9 0 (0)   
Nodal status       
   Node-negative 286 32 (11) 0.04 273 71 (26) 0.92
   Node-positive 142 26 (18) 137 35 (26)   
Histology       
   Ductal 349 45 (13) 0.33 337 85 (25) 0.54
   Lobular 65 12 (19) 60 16 (27)   
   Others 16 1 (6) 16 6 (38)   
Grading       
   I 58 6 (10) 0.11 57 14 (25) 0.76
   II 270 32 (12) 255 64 (25)   
   III 102 20 (20) 101 29 (29)   
ER status       
   Negative 60 13 (22) 0.05 57 15 (26) 0.93
   Positive 371 45 (12) 357 92 (26)   
PR status       
   Negative 75 17 (23) 0.01 70 25 (36) 0.04
   Positive 356 41 (12) 344 82 (24)   
HER2       
   Negative 380 49 (13) 0.35 365 89 (24) 0.06
   Positive 51 9 (18) 49 18 (37)   
Bone marrow status       
   Positive 106 20 (19) 0.05    
   Negative 299 34 (11)     
Immunhistochemical subtype       
   (ER-, PR-, HER2-) 26 8 (30) 0.01 23 7 (30) 0.62
   (ER-, PR-, HER2+) 11 0 11 4 (36)   
   (ER+ and/or PR+) 394 50 (13) 380 96 (25)   
  1. ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; PR, progesterone receptor.