Table 5 Association between FOXA1 and GATA3 expression, clinicopathological features and immunohistochemical markers in ER-negative cohort
Variable | n | FOXA1-negative (%) | FOXA1-positive (%) | P value | n | GATA3-negative (%) | GATA3-positive (%) | P value |
|---|---|---|---|---|---|---|---|---|
Tumour size | 80 | 36.7 ± 24.2 (65) | 36.6 ± 24.8 (15) | 0.987 | 74 | 34.46 ± 23.6 (60) | 43.4 ± 27.4 (14) | 0.229 |
Lymphovascular invasion | 83 | 78 | ||||||
Present | 35 | 29 (82.8) | 6 (17.2) | 0.391 | 35 | 29 (82.8) | 6 (17.2) | 0.867 |
Absent | 48 | 36 (75) | 12 (25) | 43 | 35 (81.4) | 8 (18.6) | ||
Lymph node stage | 83 | 78 | ||||||
Negative | 48 | 36 (75) | 12 (25) | 0.456 | 43 | 35 (81.4) | 8 (18.6) | 0.609 |
1 to 3 lymph nodes | 12 | 11 (91.7) | 1 (8.3) | 12 | 11 (91.7) | 1 (8.3) | ||
>3 lymph nodes | 23 | 18 (78.3) | 5 (21.7) | 23 | 18 (78.3) | 5 (21.7) | ||
Grade | 87 | 80 | ||||||
Grade I | 8 | 6 (75) | 2 (25) | 0.166 | 8 | 8 (100) | 0 (0) | 0.366 |
Grade II | 33 | 23 (69.7) | 10 (30.3) | 28 | 22 (78.6) | 6 (21.4) | ||
Grade III | 46 | 40 (86.9) | 6 (13.1) | 44 | 36 (81.8) | 8 (18.2) | ||
Nottingham Prognostic Index | 76 | 71 | ||||||
<3.4 | 11 | 9 (81.8) | 2 (18.2) | 0.982 | 10 | 9 (90) | 1 (10) | 0.615 |
3.4 to 5.4 | 34 | 27 (79.4) | 7 (20.6) | 32 | 26 (81.3) | 6 (18.7) | ||
>5.4 | 31 | 25 (80.6) | 6 (19.4) | 29 | 22 (75.8) | 7 (24.2) | ||
HER-2 | 85 | 79 | ||||||
Positive | 26 | 23 (88.5) | 3 (11.5) | 0.254 | 26 | 24 (92.3) | 2 (7.7) | 0.102 |
Negative | 59 | 46 (77.9) | 13 (22.1) | 53 | 41 (77.4) | 12 (22.6) | ||
EGFR | 86 | 80 | ||||||
Positive | 12 | 10 (83.3) | 2 (16.7) | 0.771 | 11 | 11 (100) | 0 (0) | 0.100 |
Negative | 74 | 59 (79.7) | 15 (20.3) | 69 | 55 (79.7) | 14 (20.3) | ||
P-cadherin | 87 | 80 | ||||||
Positive | 53 | 45 (84.9) | 8 (15.1) | 0.107 | 52 | 47 (90.4) | 5 (9.6) | 0.011 |
Negative | 34 | 24 (70.6) | 10 (29.4) | 28 | 19 (67.8) | 9 (32.2) | ||
Cytokeratin 5 | 87 | 80 | ||||||
Positive | 33 | 28 (84.8) | 5 (15.2) | 0.318 | 32 | 29 (90.6) | 3 (9.4) | 0.118 |
Negative | 54 | 41 (75.9) | 13 (24.1) | 48 | 37 (77.1) | 11 (22.9) | ||
Cytokeratin 14 | 85 | 78 | ||||||
Positive | 14 | 13 (92.8) | 1 (7.2) | 0.188 | 14 | 14 (100) | 0 (0) | 0.053 |
Negative | 71 | 55 (77.5) | 16 (22.5) | 64 | 50 (78.1) | 14 (21.9) | ||
Vimentin | 82 | 75 | ||||||
Positive | 27 | 25 (92.6) | 2 (7.4) | 0.074 | 25 | 24 (96) | 1 (4) | 0.064 |
Negative | 55 | 42 (76.4) | 13 (23.6) | 50 | 40 (80) | 10 (20) | ||
FOXA1 | - | 78 | ||||||
Positive | - | - | - | - | 15 | 6 (40) | 9 (60) | <0.0001 |
Negative | - | - | - | 63 | 58 (92.1) | 5 (7.9) | ||
GATA-3 | 78 | - | ||||||
Positive | 14 | 5 (35.7) | 9 (64.3) | <0.0001 | - | - | - | - |
Negative | 64 | 58 (90.6) | 6 (9.4) | - | - | - |