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Table 5 Association between FOXA1 and GATA3 expression, clinicopathological features and immunohistochemical markers in ER-negative cohort

From: Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours

Variable n FOXA1-negative (%) FOXA1-positive (%) P value n GATA3-negative (%) GATA3-positive (%) P value
Tumour size 80 36.7 ± 24.2 (65) 36.6 ± 24.8 (15) 0.987 74 34.46 ± 23.6 (60) 43.4 ± 27.4 (14) 0.229
Lymphovascular invasion 83     78    
   Present 35 29 (82.8) 6 (17.2) 0.391 35 29 (82.8) 6 (17.2) 0.867
   Absent 48 36 (75) 12 (25)   43 35 (81.4) 8 (18.6)  
Lymph node stage 83     78    
   Negative 48 36 (75) 12 (25) 0.456 43 35 (81.4) 8 (18.6) 0.609
   1 to 3 lymph nodes 12 11 (91.7) 1 (8.3)   12 11 (91.7) 1 (8.3)  
   >3 lymph nodes 23 18 (78.3) 5 (21.7)   23 18 (78.3) 5 (21.7)  
Grade 87     80    
   Grade I 8 6 (75) 2 (25) 0.166 8 8 (100) 0 (0) 0.366
   Grade II 33 23 (69.7) 10 (30.3)   28 22 (78.6) 6 (21.4)  
   Grade III 46 40 (86.9) 6 (13.1)   44 36 (81.8) 8 (18.2)  
Nottingham Prognostic Index 76     71    
   <3.4 11 9 (81.8) 2 (18.2) 0.982 10 9 (90) 1 (10) 0.615
   3.4 to 5.4 34 27 (79.4) 7 (20.6)   32 26 (81.3) 6 (18.7)  
   >5.4 31 25 (80.6) 6 (19.4)   29 22 (75.8) 7 (24.2)  
HER-2 85     79    
   Positive 26 23 (88.5) 3 (11.5) 0.254 26 24 (92.3) 2 (7.7) 0.102
   Negative 59 46 (77.9) 13 (22.1)   53 41 (77.4) 12 (22.6)  
EGFR 86     80    
   Positive 12 10 (83.3) 2 (16.7) 0.771 11 11 (100) 0 (0) 0.100
   Negative 74 59 (79.7) 15 (20.3)   69 55 (79.7) 14 (20.3)  
P-cadherin 87     80    
   Positive 53 45 (84.9) 8 (15.1) 0.107 52 47 (90.4) 5 (9.6) 0.011
   Negative 34 24 (70.6) 10 (29.4)   28 19 (67.8) 9 (32.2)  
Cytokeratin 5 87     80    
   Positive 33 28 (84.8) 5 (15.2) 0.318 32 29 (90.6) 3 (9.4) 0.118
   Negative 54 41 (75.9) 13 (24.1)   48 37 (77.1) 11 (22.9)  
Cytokeratin 14 85     78    
   Positive 14 13 (92.8) 1 (7.2) 0.188 14 14 (100) 0 (0) 0.053
   Negative 71 55 (77.5) 16 (22.5)   64 50 (78.1) 14 (21.9)  
Vimentin 82     75    
   Positive 27 25 (92.6) 2 (7.4) 0.074 25 24 (96) 1 (4) 0.064
   Negative 55 42 (76.4) 13 (23.6)   50 40 (80) 10 (20)  
FOXA1 -     78    
   Positive - - - - 15 6 (40) 9 (60) <0.0001
   Negative - - -   63 58 (92.1) 5 (7.9)  
GATA-3 78     -    
   Positive 14 5 (35.7) 9 (64.3) <0.0001 - - - -
   Negative 64 58 (90.6) 6 (9.4)   - - -  
  1. ER, oestrogen receptor; EGFR, epidermal growth factor receptor; FOXA-1, forkhead box A1; GATA-3, GATA binding protein 3; HER-2, human epidermal growth factor receptor 2.