Volume 11 Supplement 1

VIII Madrid Breast Cancer Conference: Latest Advances in Breast Cancer

Open Access

Clinical features and prognosis of triple-negative breast cancer

  • M Izquierdo Sanz1,
  • A Alsina Maqueda1,
  • M Cabero Riera1,
  • R Fabregas Xaurado1,
  • F Tresserra Casas2,
  • M Cusido Gimferrer1,
  • C Ara Perez1 and
  • A Úbeda Hernandez1
Breast Cancer Research200911(Suppl 1):P26

https://doi.org/10.1186/bcr2309

Published: 23 June 2009

Objective

To compare the clinical features and prognosis of triple-negative breast cancers.

Methods

Analysis of all breast cancers studied by the Breast Diseases Committee during the period 2000 to 2005, comparing the clinical features and prognosis of triple-negative with the rest of breast cancers. The overall survival, local recurrence and contralateral breast cancer were analyzed with Kaplan–Meier curves.

Results

We studied 345 breast cancers, 22 (6.4%) triple negative and 323 (93.6%) nontriple negative. In the triple negative, the tumour size was pT0 0 (0%), pT1a 1 (7.1%), pT1b 1 (7.1%), pT1c 8 (57.1%), pT2 3 (21.4%), pT4b 1 (7.1%); and the axillary lymph node was pN0 9 (64.3%), pN1 5 (35.7%), with no statistically significant differences for the nontriple negative. The histological grade was grade III in 52.9% of the cases of triple-negative breast cancer and in 13.8% of the cases of nontriple-negative breast cancer; these differences were statistically significant. The overall survival was statistically worse, the local recurrences and contralateral breast cancer were higher in triple negative.

Conclusion

Triple-negative breast cancer has a high histological grade, more metastases, more local recurrences and contralateral breast cancer, and worse overall survival.

Authors’ Affiliations

(1)
Department of Obstetrics, Gynecology and Reproductive Medicine, and Institut, Universitari Dexeus
(2)
Department Histology, Institut Universitari Dexeus

Copyright

© BioMed Central Ltd. 2009

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