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Clinical features and prognosis of triple-negative breast cancer
Breast Cancer Research volume 11, Article number: P26 (2009)
To compare the clinical features and prognosis of triple-negative breast cancers.
Analysis of all breast cancers studied by the Breast Diseases Committee during the period 2000 to 2005, comparing the clinical features and prognosis of triple-negative with the rest of breast cancers. The overall survival, local recurrence and contralateral breast cancer were analyzed with Kaplan–Meier curves.
We studied 345 breast cancers, 22 (6.4%) triple negative and 323 (93.6%) nontriple negative. In the triple negative, the tumour size was pT0 0 (0%), pT1a 1 (7.1%), pT1b 1 (7.1%), pT1c 8 (57.1%), pT2 3 (21.4%), pT4b 1 (7.1%); and the axillary lymph node was pN0 9 (64.3%), pN1 5 (35.7%), with no statistically significant differences for the nontriple negative. The histological grade was grade III in 52.9% of the cases of triple-negative breast cancer and in 13.8% of the cases of nontriple-negative breast cancer; these differences were statistically significant. The overall survival was statistically worse, the local recurrences and contralateral breast cancer were higher in triple negative.
Triple-negative breast cancer has a high histological grade, more metastases, more local recurrences and contralateral breast cancer, and worse overall survival.
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Sanz, M.I., Maqueda, A.A., Riera, M.C. et al. Clinical features and prognosis of triple-negative breast cancer. Breast Cancer Res 11 (Suppl 1), P26 (2009). https://doi.org/10.1186/bcr2309