Table 1 Age-specific incidence rates of breast cancer
From: A constant risk for familial breast cancer? A population-based family study
Age of mothers (years) | Cases (n) | IR (95%CI)a |
|---|---|---|
Daughter age at diagnosis <35 | ||
<40 | 23 | 0.40 (0.25–0.60) |
40–44 | 23 | 0.36 (0.23–0.54) |
45–49 | 28 | 0.38 (0.25–0.55) |
50–54 | 32 | 0.43 (0.29–0.60) |
55–59 | 30 | 0.42 (0.28–0.60) |
60–64 | 22 | 0.42 (0.26–0.64) |
65–69 | 25 | 0.43 (0.28–0.63) |
70–74 | 14 | 0.39 (0.21–0.65) |
75–79 | 8 | 0.34 (0.14–0.64) |
80–84 | 6 | 0.43 (0.16–0.94) |
All ages | 211 | 0.40 (0.35–0.46) |
Increase in IR per 5-year age categoryb | 0.97 (0.90–1–04) | |
Test for linear trendb | P = 0.32 | |
Daughter age at diagnosis 35 to 44 | ||
40–44 | 21 | 0.27 (0.19–0.38) |
45–49 | 91 | 0.29 (0.23–0.36) |
50–54 | 105 | 0.30 (0.25–0.36) |
55–59 | 100 | 0.28 (0.22–0.34) |
60–64 | 116 | 0.33 (0.27–0.40) |
65–69 | 125 | 0.40 (0.34–0.48) |
70–74 | 108 | 0.44 (0.36–0.53) |
75–79 | 75 | 0.43 (0.34–0.54) |
80–84 | 46 | 0.44 (0.33–0.59) |
All ages | 787 | 0.34 (0.32–0.37) |
Increase in IR per 5-year age categoryb | 1.03 (0.98–1.07) | |
Test for linear trendb | P = 0.11 | |
Age at diagnosis in daughters 45–54 | ||
50–54 | 75 | 0.23 (0.18–0.29) |
55–59 | 165 | 0.23 (0.20–0.27) |
60–64 | 212 | 0.29 (0.25–0.33) |
65–69 | 272 | 0.40 (0.35–0.45) |
70–74 | 226 | 0.38 (0.33–0.43) |
75–79 | 181 | 0.39 (0.33–0.45) |
80–84 | 140 | 0.47 (0.39–0.55) |
All ages | 1,271 | 0.33 (0.31–0.35) |
Increase in IR per 5-year age categoryb | 1.06 (1.02–1.11) | |
Test for linear trendb | P = 0.003 | |
Age at diagnosis in daughters ≥55 | ||
60–64 | 77 | 0.25 (0.20–0.31) |
65–69 | 169 | 0.35 (0.30–0.40) |
70–74 | 184 | 0.35 (0.30–0.41) |
75–79 | 156 | 0.35 (0.30–0.41) |
80–84 | 147 | 0.45 (0.38–0.53) |
All ages | 733 | 0.35 (0.33–0.38) |
Increase in IR per 5-year age categoryb | 1.09 (1.01–1.17) | |
Test for linear trendb | P = 0.02 | |
All ages at diagnosis in daughters | ||
<40 | 23 | 0.40 (0.25–0.60) |
40–44 | 44 | 0.27 (0.20–0.36) |
45–49 | 119 | 0.31 (0.26–0.37) |
50–54 | 212 | 0.28 (0.25–0.32) |
55–59 | 295 | 0.26 (0.23–0.29) |
60–64 | 427 | 0.30 (0.27–0.33) |
65–69 | 591 | 0.38 (0.35–0.42) |
70–74 | 532 | 0.38 (0.35–0.41) |
75–79 | 420 | 0.38 (0.34–0.42) |
80–84 | 339 | 0.46 (0.41–0.51) |
All ages | 3,002 | 0.34 (0.33–0.36) |
Increase in IR per 5-year age categoryb | 1.02 (1.00–1.04) | |
Test for linear trendb | P = 0.03 | |
Heterogeneityc | P = 0.0002 | |