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Table 5 Cox univariate regression analyses of variables in relation to disease-free survival and overall survival

From: Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors

Variable Disease-free survival Overall survival
  P value Relative risk (95% CI) P value Relative risk (95% CI)
Tumor grade 0.0201 1.767 (1.093 to 2.86) 0.0072 1.785 (1.170 to 2.725)
Tumor size 0.0007 2.070 (1.357 to 3.160) 0.0052 1.662 (1.164 to 2.375)
Nodal status <0.0001 3.193 (2.091 to 4.876) <0.0001 2.205 (1.545 to 3.148)
HER2 0.0037 2.470 (1.342 to 4.546) 0.0595 1.739 (0.978 to 3.093)
pHER1 0.0346 1.683 (1.038 to 2.726) 0.2317 1.309 (0.842 to 2.033)
pHER2 <0.0001 2.699 (1.662 to 4.384) 0.0002 2.273 (1.470 to 3.513)
pHER3 0.0489 1.686 (1.002 to 2.835) 0.3926 1.233 (0.763 to 1.995)
HER4 <0.0001 0.361 (0.238 to 0.549) 0.0111 0.624 (0.433 to 0.898)
  1. Variables were analyzed as follows: tumor grade (1 and 2 vs. 3), tumor size (<25 mm vs. ≥ 25 mm), nodal status (0 vs. ≥ 1), HER2 (negative vs. positive), pHER1 (negative vs. positive), pHER2 (negative and weak vs. strong), pHER3 (negative vs. positive), HER4 (low vs. high). 95% CI, 95% confidence interval. Bold data represent significant values.