Breast Cancer Research

Table 3 Correlations between protein expression levels

From: Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors

	HER2		pHER1		pHER2			pHER3		HER4		pErk
	(-)	(+)	(-)	(+)	(-)	Weak	Strong	(-)	(+)	Low	High	(-)	Moderate	Strong
pHER1
Negative	202	15
Positive	40	7
P value	0.083
pHER2
Negative	154	1	148	7
Weak	65	6	55	15
Strong	23	15	13	25
P value	<0.0001 (+)		<0.0001 (+)
pHER3
Negative	211	10	199	21	144	61	14
Positive	28	12	13	26	6	10	24
P value	<0.0001 (+)		<0.0001 (+)		<0.0001 (+)
HER4
Low	75	10	69	16	49	16	19	71	13
High	163	12	142	31	102	53	19	145	27
P value	0.234		0.865		0.021 (-)			1.000
pErk
Negative	103	10	97	16	70	25	17	99	12	44	65
Moderate	56	5	47	14	31	21	9	52	9	17	42
Strong	75	7	65	15	46	24	11	64	17	22	60
P value	1.000		0.328		0.495			0.146		0.073
pAkt
Negative	66	4	63	7	55	9	6	64	4	28	39	48	15	7
Moderate	99	7	88	17	58	30	17	87	17	34	71	40	22	37
Strong	74	11	64	21	40	30	15	66	18	21	62	23	22	37
P value	0.213		0.057		0.002 (+)			0.021(+)		0.102		<0.0001 (+)

Fisher's exact test was used to obtain the P values. (+) and (-), positive and negative correlations. Bold data represent significant values.

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ISSN: 1465-542X

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