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Table 3 Correlations between protein expression levels

From: Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors

  HER2 pHER1 pHER2 pHER3 HER4 pErk
  (-) (+) (-) (+) (-) Weak Strong (-) (+) Low High (-) Moderate Strong
pHER1               
   Negative 202 15             
   Positive 40 7             
   P value 0.083             
pHER2               
   Negative 154 1 148 7           
   Weak 65 6 55 15           
   Strong 23 15 13 25           
   P value <0.0001 (+) <0.0001 (+)           
pHER3               
   Negative 211 10 199 21 144 61 14        
   Positive 28 12 13 26 6 10 24        
   P value <0.0001 (+) <0.0001 (+) <0.0001 (+)         
HER4               
   Low 75 10 69 16 49 16 19 71 13      
   High 163 12 142 31 102 53 19 145 27      
   P value 0.234 0.865 0.021 (-)   1.000      
pErk               
   Negative 103 10 97 16 70 25 17 99 12 44 65    
   Moderate 56 5 47 14 31 21 9 52 9 17 42    
   Strong 75 7 65 15 46 24 11 64 17 22 60    
   P value 1.000 0.328 0.495 0.146 0.073    
pAkt               
   Negative 66 4 63 7 55 9 6 64 4 28 39 48 15 7
   Moderate 99 7 88 17 58 30 17 87 17 34 71 40 22 37
   Strong 74 11 64 21 40 30 15 66 18 21 62 23 22 37
   P value 0.213 0.057 0.002 (+) 0.021(+) 0.102 <0.0001 (+)
  1. Fisher's exact test was used to obtain the P values. (+) and (-), positive and negative correlations. Bold data represent significant values.