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Table 4 Comparison of extremes of phenotypic subgroups

From: The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer

Phenotype

Gene

SNP

Risk allele

Frequency

Trend test

Genotypic P value

    

ER positive

ER negative

P value

OR (95% CI)

 

ER (+/-)

FGFR2

rs2981582

A

0.478

0.3608

0.000003*

1.62 (1.32 to 2.00)

0.000014

 

FGFR2

rs1219648

G

0.4861

0.3736

0.000008*

1.59 (1.29 to 1.95)

0.000039

 

ATM

rs1801516

A

0.1085

0.1776

0.000273*

0.56 (0.42 to 0.75)

0.000402

 

TOX3

rs1420546

C

0.3655

0.2865

0.002135

1.44 (1.15 to 1.79)

0.003002

 

ATM

rs3092991

G

0.1248

0.1813

0.002561

0.64 (0.49 to 0.85)

0.00212

Grade (1/3)

ESR1

rs2228480

A

0.2178

0.1032

0.002962

2.42 (1.34 to 4.38)

NA

 

ESR1

rs3798577

C

0.5088

0.373

0.004411

1.74 (1.19 to 2.55)

0.002136

 

IGF1

rs2373721

G

0.25

0.1406

0.007009

2.04 (1.21 to 3.42)

NA

 

LSP1

rs661348

C

0.3694

0.4921

0.009682

0.60 (0.42 to 0.88)

0.01541

  1. The genotypic test is not performed if at least one of the cells has a frequency less than 5 which is represented by NA. *Significant SNPs after correcting for 82 independent tests. CI, confidence interval; ER, oestrogen receptor; OR, odds ratio; SNP, single nuceotide polymorphism.
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Breast Cancer Research

ISSN: 1465-542X

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