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Table 2 Descriptive statistics of studies in the meta-analysis

From: A functional Notchsurvivin gene signature in basal breast cancer

Study Total n Subset Survivin Notch-1 Keratin 5
    Mean SEM P Mean SEM P Mean SEM P
Chin and colleagues [55] 118 ER- (n = 43) 0.7723 0.0815 1.353 × 10-5 0.7793 0.0548 2.231 × 10-5 0.9844 0.1436 4.893 × 10-6
   ER+ (n = 75) 0.3371 0.0437   0.5027 0.0245   0.1884 0.0678  
Desmedt and colleagues [56] 198 ER- (n = 64) 0.7238 0.0478 1.414 × 10-8 0.3254 0.0389 3.951 × 10-4 0.6649 0.0996 1.159 × 10-2
   ER+ (n = 134) 0.3278 0.0460   0.1658 0.0193   0.3773 0.0507  
Ginestier and colleagues [57] 55 ER- (n = 28) 0.7621 0.1251 9.689 × 10-5 1.4343 0.0504 2.933 × 10-4 1.2587 0.2116 1.219 × 10-2
   ER+ (n = 27) 0.4959 0.0954   1.1536 0.0520   0.5842 0.1492  
Hess and colleagues [58] 133 ER- (n = 51) 0.0776 0.0451 2.071 × 10-3 0.2169 0.0454 1.203 × 10-1 0.5110 0.1706 1.165 × 10-4
   ER+ (n = 82) -0.0956 0.0309   0.1238 0.0384   -0.2216 0.0480  
Ivshina and colleagues [59] 249a ER- (n = 34) 0.4877 0.0847 1.064e × 10-7 0.3819 0.0589 1.643 × 10-2 0.7071 0.1683 1.403 × 10-1
   ER+ (n = 211) -0.0950 0.0408   0.2299 0.0137   0.4438 0.0479  
Miller and colleagues [60] 251 ER- (n = 34) 0.3701 0.0681 2.780 × 10-8 0.3011 0.0443 2.073 × 10-2 0.4714 0.1310 2.638 × 10-1
   ER+ (n = 213) -0.1337 0.0382   0.1905 0.0113   0.3165 0.0389  
Minn and colleagues [61] 82 ER- (n = 42) 0.1969 0.0719 1.809 × 10-4 0.4515 0.0529 7.897 × 10-5 1.1060 0.1311 2.391 × 10-6
   ER+ (n = 57) -0.1821 0.0652   0.2036 0.0247   0.2624 0.1028  
Richardson and colleagues [62] 39 ER- (n = 24) -0.1141 0.1363 6.374 × 10-3 1.1360 0.0621 1.216 × 10-1 1.1878 0.1436 4.670e × 10-3
   ER+ (n = 15) -0.6187 0.1089   1.0139 0.0457   0.6193 0.1225  
Saal and colleagues [37] 105 ER- (n = 60) -1.3798 0.1075 5.143 × 10-6 0.2043 0.0756 3.033 × 10-3    
   ER+ (n = 45) -2.1290 0.1121   -0.1145 0.0728     
Sotiriou and colleagues [63] 119 ER- (n = 34) 0.4834 0.0320 2.528 × 10-3 0.2702 0.0565 1.323 × 10-4 0.9849 0.1107 9.396 × 10-3
   ER+ (n = 85) 0.3691 0.0166   0.0181 0.0196   0.6560 0.0499  
Turashvili [32] 10 ER- (n = 3) 0.1268 0.1688 2.533 × 10-1 1.1991 0.1243 3.082 × 10-1 0.6117 0.3735 6.750 × 10-1
   ER+ (n = 7) -0.2686 0.2733   1.0239 0.0709   0.3655 0.4358  
van de Vijver and colleagues [64] 295 ER- (n = 69) 0.3719 0.2218 1.847 × 10-12 0.6277 0.1148 1.418 × 10-10 -0.7917 0.4073 1.748 × 10-5
   ER+ (n = 226) -1.7301 0.1580   -0.2900 0.0590   -2.8083 0.1822  
Wang and colleagues [65] 286 ER- (n = 77) 0.0902 0.0459 2.284 × 10-8 0.4139 0.0282 2.255 × 10-11 0.8906 0.0819 3.242 × 10-7
   ER+ (n = 209) -0.2387 0.0318   0.1784 0.0151   0.3844 0.0459  
Yu and colleagues [38] 68 (19) ER- (n = 15) -0.2546 0.0874 1.689 × 10-1 -0.2712 0.1090 1.946 × 10-4 1.8394* 0.2312* 2.280 × 10-2 *
   ER+ (n = 4) -0.4225 0.0831   0.7625 0.0431   0.9196* 0.2431*  
Zhao and colleagues (lobular) [36] 16 ER- (n = 4) -2.4418 0.2721 6.851 × 10-1 0.0416 0.4079 7.011 × 10-1    
   ER+ (n = 12) -2.3108 0.1269   -0.1367 0.1083     
Zhao and colleagues (ductal) [36] 34 ER- (n = 11) -1.4613 0.2938 1.440 × 10-1 0.3298 0.3722 1.769 × 10-1    
   ER+ (n = 23) -2.0013 0.1981   -0.2272 0.1104     
  1. Mean, standard error of mean (SEM), and P value between estrogen receptor-negative (ER-) and estrogen receptor-positive (ER+) breast cancers are presented for Notch-1, survivin, and keratin-5 expression in the analyzed datasets. aUppsala cohort. * Subset of samples with keratin-5 data.