A candidate molecular signature associated with tamoxifen failure in primary breast cancer

Breast Cancer Research

Table 4 Statistical comparison of the mRNA levels measured by RTQ-PCR between the control and TF groups of tumor samples (Ninewells Hospital, Dundee, UK)

Genes	Tumor samples	Number of samples	mRNA levels (arbitrary units)
			Median	Range	P ^a
ESR1	Control	17	72.71	28.14 to 261.30	<10^-6
	TF	18	1.98	0.13 to 20.85
IGFBP4	Control	17	2.53	1.44 to 5.93	0.0004
	TF	18	1.12	0.15 to 3.24
MET	Control	17	0.48	0.15 to 2.46	0.009
	TF	18	1.23	0.18 to 12.51
FOS	Control	17	0.36	0.04 to 2.54	0.02
	TF	18	0.15	0.02 to 1.46
SNCG	Control	17	0.78	0.08 to 34.01	0.036
	TF	18	0.31	0.05 to 4.39
BCL2	Control	17	2.87	0.08 to 7.14	0.04
	TF	18	1.08	0.13 to 6.8

^aP value (Mann-Whitney test) was considered significant when P < 0.05. TF, tamoxifen failure.

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