YB-1 expression is associated with relapse and poor survival in the entire cohort. (a) Out of a total of 1,201 patients, YB-1 was expressed in 41% (495/1201) with recurrent breast cancer. YB-1 expression was associated with shorter relapse free survival. 'N' represents the number of patients who had breast cancer recurrence (number of events). (b) The expression of YB-1 is associated with a significant increase in breast cancer specific deaths (BCSS). YB-1 was expressed in 35% (1,081/3,097) of patients with reduced BCSS. Patient survival was based on deaths specifically related to breast cancer and not other causes. BCSS = breast cancer specific survival; YB-1 = Y-box binding protein-1.